1-Bromo-4-methoxy-2-phenylmethoxybenzene

Base Information

• Chemical Name: 1-Bromo-4-methoxy-2-phenylmethoxybenzene
• CAS No.: 150356-67-5
• Molecular Formula: C14H13 Br O2
• Molecular Weight: 293.16
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID50593735
• Nikkaji Number: J3.373.692D
• Wikidata: Q82488263
• Mol file: 150356-67-5.mol

Synonyms:150356-67-5;1-Bromo-4-methoxy-2-phenylmethoxybenzene;2-(Benzyloxy)-1-bromo-4-methoxybenzene;3-Benzyloxy-4-bromoanisole;SCHEMBL7390468;DTXSID50593735;GPNMWTHCRMWAFR-UHFFFAOYSA-N;2-benzyloxy-4-methoxyphenyl bromide;MFCD07367815;2-benzyloxy-1-bromo-4-methoxybenzene;AKOS015961470;AB31293;AC-13983;BS-21529;1-bromo4-methoxy-2-(phenylmethoxy)benzene;1-bromo-4-methoxy-2-(phenylmethoxy)benzene;CS-0195327;E90054;Benzene, 1-bromo-4-methoxy-2-(phenylmethoxy)-;A928640;J-008690

Chemical Property of 1-Bromo-4-methoxy-2-phenylmethoxybenzene

Chemical Property:

• Vapor Pressure: 1.43E-05mmHg at 25°C
• Refractive Index: 1.584
• Boiling Point: 377.8°Cat760mmHg
• Flash Point: 166.1°C
• PSA: 18.46000
• Density: 1.367g/cm³
• LogP: 4.03670
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 292.00989
• Heavy Atom Count: 17
• Complexity: 216

Purity/Quality:

98%min ^*data from raw suppliers

3-Benzyloxy-4-bromoanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)Br)OCC2=CC=CC=C2
• Uses: 3-Benzyloxy-4-bromoanisole is used for synthesis of demethylwedelolactone.

Technology Process of 1-Bromo-4-methoxy-2-phenylmethoxybenzene

There total 8 articles about 1-Bromo-4-methoxy-2-phenylmethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-5-methoxyphenol (63604-94-4) + water (7732-18-5) + potassium carbonate (584-08-7) + benzyl chloride (100-44-7) + acetonitrile (75-05-8,26809-02-9) → 1-bromo-4-methoxy-2-(phenylmethoxy)benzene (150356-67-5)

Guidance literature:

With Ki; nitrogen; In ethyl acetate;

Reference yield: 91.0%

3-(benzyloxy)-4-bromophenol (70120-18-2) + methyl iodide (74-88-4) → 1-bromo-4-methoxy-2-(phenylmethoxy)benzene (150356-67-5)

Guidance literature:

With potassium carbonate; In ethanol; for 16h; Inert atmosphere; Reflux;

DOI:10.1246/bcsj.20110309

Reference yield: 80.0%

2-Benzyloxy-1-bromo-4-fluoro-benzene (202857-88-3) + methanol (67-56-1) → 1-bromo-4-methoxy-2-(phenylmethoxy)benzene (150356-67-5)

Guidance literature:

methanol; With potassium tert-butylate; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h; prs;

2-Benzyloxy-1-bromo-4-fluoro-benzene; In N,N-dimethyl-formamide; at 80 ℃; for 20h; Further stages.;

DOI:10.1016/j.tetlet.2008.05.091

upstream raw materials:

2-bromo-5-methoxyphenol

benzyl bromide

water

potassium carbonate

Downstream raw materials:

2-(2-benzyloxy-4-methoxybenzoyl)-3-pyridinecarboxylic acid

3-(2-benzyloxy-4-methoxybenzoyl)-2-(methoxycarbonyl)pyridine

2,2'-bis(benzyloxy)-4,4'-dimethoxybiphenyl

2,2'-dihydroxy-4,4'-dimethoxybiphenyl

Refernces

• 1、 Aikawa, Kohsuke,Miyazaki, Yoshitaka,Mikami, Koichi. "Stable axial chirality in metal complexes bearing 4,4′-substituted BIPHEPs: Application to catalytic asymmetric carbon-carbon bond-forming reactions". . p. 201 - 208. Retrieved 2012/04/23.
• 2、 -. "DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS". Page/Page column 265-268. . Retrieved 2008/06/13.