4-CHLORO-5-NITROPYRIMIDINE

Base Information

• Chemical Name: 4-CHLORO-5-NITROPYRIMIDINE
• CAS No.: 150943-50-3
• Molecular Formula: C4H2 Cl N3 O2
• Molecular Weight: 159.53
• Hs Code.: 2933599090
• Mol file: 150943-50-3.mol

Synonyms:4-CHLORO-5-NITROPYRIMIDINE;PYRIMIDINE, 4-CHLORO-5-NITRO-

Chemical Property of 4-CHLORO-5-NITROPYRIMIDINE

Chemical Property:

• Boiling Point: 291.3±20.0 °C(Predicted)
• PKA: -3.17±0.16(Predicted)
• PSA: 71.60000
• Density: 1.600±0.06 g/cm3(Predicted)
• LogP: 1.56140
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloro-5-nitropyrimidine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-5-NITROPYRIMIDINE

There total 1 articles about 4-CHLORO-5-NITROPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.4%

4-hydroxyl-5-nitropyrimidine (3749-47-1) → 4-chloro-5-nitropyrimidine (150943-50-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In toluene; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2018.03.024

Reference yield:

4-chloro-5-nitropyrimidine (150943-50-3) + 1,4-phenylenediamine (106-50-3) → N-(5-nitropyrimidin-4-yl)benzene-1,4-diamine (1353677-33-4)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 20 ℃;

upstream raw materials:

4-hydroxyl-5-nitropyrimidine

Downstream raw materials:

N-(5-nitropyrimidin-4-yl)benzene-1,4-diamine

Refernces

• 1、 Cui, Guonan,Jin, Jing,Chen, Hualong,Cao, Ran,Chen, Xiaoguang,Xu, Bailing. "Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors". supporting information. p. 2186 - 2197. Retrieved 2018/03/28.