2-BROMO-1-(2-ETHOXY-PHENYL)-ETHANONE

Base Information

• Chemical Name: 2-BROMO-1-(2-ETHOXY-PHENYL)-ETHANONE
• CAS No.: 152074-07-2
• Molecular Formula: C10H11 Br O2
• Molecular Weight: 243.1
• Hs Code.: 2914700090
• Mol file: 152074-07-2.mol

Synonyms:2-BROMO-1-(2-ETHOXY-PHENYL)-ETHANONE

Chemical Property of 2-BROMO-1-(2-ETHOXY-PHENYL)-ETHANONE

Chemical Property:

• PSA: 26.30000
• LogP: 2.66290

Purity/Quality:

99%min ^*data from raw suppliers

2-Bromo-1-(2-ethoxyphenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromo-1-(2-ethoxyphenyl)ethanone is used as a reagent in the preparation of aroylfurans and aroylthiophenes which are used in the treatment of neoplastic and autoimmune diseases.

Technology Process of 2-BROMO-1-(2-ETHOXY-PHENYL)-ETHANONE

There total 3 articles about 2-BROMO-1-(2-ETHOXY-PHENYL)-ETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.08%

1-(2-ethoxyphenyl)ethanone (2142-67-8) → 2-bromo-1-(2-ethoxyphenyl)ethan-1-one (152074-07-2)

Guidance literature:

With copper(ll) bromide; In ethyl acetate; at 80 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2020.115574

Reference yield:

o-hydroxyacetophenone (118-93-4,104809-67-8) → 2-bromo-1-(2-ethoxyphenyl)ethan-1-one (152074-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

2: bromine / diethyl ether / 20 °C / Darkness

With bromine; potassium carbonate; In diethyl ether; N,N-dimethyl-formamide;

Reference yield:

→ 2-bromo-1-(2-ethoxyphenyl)ethan-1-one (152074-07-2)

Guidance literature:

upstream raw materials:

o-hydroxyacetophenone

1-(2-ethoxyphenyl)ethanone

Downstream raw materials:

4-(2-ethoxyphenyl)-2-<<4(5)-methyl-5(4)-imidazolyl>methyl>thiazole

Refernces

• 1、 -. "NADPH OXIDASE INHIBITORS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND APPLICATION THEREOF". . . Retrieved 2020/01/11.