7-Epi-docetaxel (Docetaxel Impurity C)

Base Information

• Chemical Name: 7-Epi-docetaxel (Docetaxel Impurity C)
• CAS No.: 153381-68-1
• Molecular Formula: C43H53 N O14
• Molecular Weight: 807.88
• Mol file: 153381-68-1.mol

Synonyms:Benzenepropanoicacid, b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxy-,12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester, [2aR-[2aa,4a,4ab,6b,9a(aR*,bS*),11b,12a,12aa,12ba]]-;7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.;7-Epidocetaxel; 7-Epitaxotere; 7-epi-Docetaxel

Chemical Property of 7-Epi-docetaxel (Docetaxel Impurity C)

Chemical Property:

• Melting Point: 138-140°C
• Boiling Point: 900.5±65.0 °C(Predicted)
• PKA: 11.20±0.46(Predicted)
• PSA: 227.94000
• Density: 1.37±0.1 g/cm3 (20 ºC 760 Torr)
• LogP: 3.46400
• Storage Temp.: Amber Vial, -20?C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

7-EpiDocetaxel ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Epi Docetaxel (Docetaxel EP Impurity C) is an isomer of Docetaxel (D494420). Docetaxel injection impurity C. An isomer of Docetaxel. Docetaxel injection impurity C An isomer of Docetaxel (D494420). Docetaxel injection

Technology Process of 7-Epi-docetaxel (Docetaxel Impurity C)

There total 2 articles about 7-Epi-docetaxel (Docetaxel Impurity C) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Docetaxel (114915-20-7,114977-28-5,114977-29-6,133577-32-9,133577-33-0) → 7-epi-docetaxel (153381-68-1)

Guidance literature:

With silver(l) oxide; In N,N-dimethyl-formamide; at 100 ℃; for 3h;

DOI:10.1002/cjoc.201600381

Reference yield:

Docetaxel (114915-20-7,114977-28-5,114977-29-6,133577-32-9,133577-33-0) → 7-epi-docetaxel (153381-68-1) + 10-oxodocetaxel (162784-72-7,167074-97-7)

Guidance literature:

With polysorbate 80; In ethanol; water; at 25 - 70 ℃; for 24 - 310h; Product distribution / selectivity; Aqueous citrate buffer;

Reference yield: 63.0%

7-epi-docetaxel (153381-68-1) → 9α-dihydro-7-epi-docetaxel

Guidance literature:

electrochemical reduction: electrolyte: MeOH, NH₄Cl, aq. NH₃, mercury cathode, platinum anode, E = -1.80 V vs. SCE electrode;

DOI:10.1016/S0040-4039(00)73303-X

upstream raw materials:

Docetaxel

Refernces

• 1、 Li, Zhao,Feng, Jia,Zou, Kun,Yang, Zhuo,Zhang, Yong,Xu, Zhijian,Li, Bo,Shi, Jiye,Li, Yiming,Zhu, Weiliang,Chen, Kaixian. "Facile Synthesis of 7-epi-Taxane and Its Derivatives and Preliminary Evaluation of Anticancer Activity". . p. 1165 - 1176. Retrieved 2016/11/25.
• 2、 -. "METHOD FOR PREPARATION OF AMORPHOUS, ANHYDROUS CRYSTALLINE OR HYDRATED CRYSTALLINE DOCETAXEL". Page/Page column 6. . Retrieved 2009/01/24.