4'-Bromo-2'-hydroxy-5'-methylacetophenone, 97%

Base Information

• Chemical Name: 4'-Bromo-2'-hydroxy-5'-methylacetophenone, 97%
• CAS No.: 50342-17-1
• Molecular Formula: C9H9BrO2
• Molecular Weight: 229.073
• Hs Code.: 2914700090
• Mol file: 50342-17-1.mol

Synonyms:4-Bromo-2-hydroxy-5-methylacetophenone;

Chemical Property of 4'-Bromo-2'-hydroxy-5'-methylacetophenone, 97%

Chemical Property:

• Melting Point: 86-89°C
• Boiling Point: 308.5 °C at 760 mmHg
• PKA: 9.72±0.23(Predicted)
• Flash Point: 140.4 °C
• PSA: 37.30000
• Density: 1.508 g/cm³
• LogP: 2.66570

Purity/Quality:

98%Min ^*data from raw suppliers

5-Bromo-2-hydroxy-4-methylacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 5-Bromo-2-hydroxy-4-methylacetophenone is used in the formation of nitrobenzofurans of the benzofuran family that is known for displaying anti-microbial properties.

Technology Process of 4'-Bromo-2'-hydroxy-5'-methylacetophenone, 97%

There total 6 articles about 4'-Bromo-2'-hydroxy-5'-methylacetophenone, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4'-hydroxy-2'-methylacetophenone (6921-64-8) → 1-(5-bromo-2-hydroxy-4-methylphenyl)ethan-1-one (50342-17-1)

Guidance literature:

With bromine; In chloroform; at -10 ℃; for 3h;

DOI:10.1002/chem.201404903

Reference yield: 80.0%

4-bromo-3-methylphenyl acetate (22012-59-5) → 1-(5-bromo-2-hydroxy-4-methylphenyl)ethan-1-one (50342-17-1)

Guidance literature:

With aluminium trichloride; at 100 - 180 ℃; for 0.166667h;

Reference yield:

3-methyl-phenol (108-39-4) → 1-(5-bromo-2-hydroxy-4-methylphenyl)ethan-1-one (50342-17-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 26.9 percent / Br₂ / CHCl₃ / 0 - 5 °C

2: 2.56 g / conc. H₂SO₄ / 0.25 h

3: 80 percent / AlCl₃ / 0.17 h / 100 - 180 °C

With aluminium trichloride; sulfuric acid; bromine; In chloroform;

upstream raw materials:

4'-hydroxy-2'-methylacetophenone

4-bromo-3-methylphenyl acetate

1-(2-amino-5-bromo-4-methyl-phenyl)-ethanone

4-bromo-3-methylphenol

Downstream raw materials:

4-Acetylamino-3-nitro-benzoic acid 2-acetyl-4-bromo-5-methyl-phenyl ester

ethyl 2-(2-acetyl-4-bromo-5-methylphenoxy)propionate

2-Hydroxy-α,α,4-trimethylbenzyl alcohol

4'-hydroxy-2'-methylacetophenone

Refernces

• 1、 Pauli, Larissa,Tannert, Re,Scheil, Robin,Pfaltz, Andreas. "Asymmetric hydrogenation of furans and benzofurans with iridium-pyridine-phosphinite catalysts". supporting information. p. 1482 - 1487. Retrieved 2015/01/30.
• 2、 Gabriel, Gabriel,Pickles, Robert,Tyman, John H. P.. "The Synthesis of Novel Substituted 1-Benzoxepine-3,5(2H,4H)-diones". . p. 2713 - 2739. Retrieved 2007/10/02.