4,5-Dichloro-3-piperidinoylisothiazole

Base Information

• Chemical Name: 4,5-Dichloro-3-piperidinoylisothiazole
• CAS No.: 56504-52-0
• Molecular Formula: C12H10N2O4
• Molecular Weight: 246.222
• Mol file: 56504-52-0.mol

Synonyms:4,5-Dichloro-3-piperidinoylisothiazole

Chemical Property of 4,5-Dichloro-3-piperidinoylisothiazole

Chemical Property:

• PSA: 44.37000
• LogP: 2.34010

Purity/Quality:

99%min ^*data from raw suppliers

4,5-DICHLORO-3-PIPERIDINOYLISOTHIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5-Dichloro-3-piperidinoylisothiazole

There total 3 articles about 4,5-Dichloro-3-piperidinoylisothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

BARBITURIC ACID (67-52-7,944357-77-1) + 3-methoxy-benzaldehyde (591-31-1) → 5-(3-methoxybenzylidene)pyrimidine-2,4,6-trione (56504-52-0)

Guidance literature:

With iron(III) chloride hexahydrate; water; for 0.333333h; Reflux; Green chemistry;

DOI:10.1039/c4ra03413a

Reference yield: 95.0%

4-Amino-2,6-dihydroxypyrimidine (873-83-6) + 3-methoxy-benzaldehyde (591-31-1) → 5-(3-methoxybenzylidene)pyrimidine-2,4,6-trione (56504-52-0)

Guidance literature:

With iron(III) chloride hexahydrate; water; for 0.333333h; Reflux; Green chemistry;

DOI:10.1039/c4ra03413a

Reference yield:

→ 5-(3-methoxybenzylidene)pyrimidine-2,4,6-trione (56504-52-0)

Guidance literature:

Barbitursaeure, m-Methoxybenzaldehyd, Ethanol, Wasser;

upstream raw materials:

BARBITURIC ACID

3-methoxy-benzaldehyde

4-Amino-2,6-dihydroxypyrimidine

Downstream raw materials:

5-(3-methoxybenzyl)pyrimidine-2,4,6(1H,3H,5H)-trione

Refernces

• 1、 Theresa, Letcy Vincent,Avudaiappan, Govindan,Shaibuna, Machingal,Hiba, Kottayil,Sreekumar, Krishnapillai. "A study on the physical properties of low melting mixtures and their use as catalysts/solvent in the synthesis of barbiturates". . p. 1849 - 1860. Retrieved 2021/06/17.
• 2、 Daneshvar, Nader,Nasiri, Mitra,Shirzad, Maryam,Safarpoor Nikoo Langarudi, Mohaddeseh,Shirini, Farhad,Tajik, Hassan. "The introduction of two new imidazole-based bis-dicationic Br?nsted acidic ionic liquids and comparison of their catalytic activity in the synthesis of barbituric acid derivatives". . p. 9744 - 9756. Retrieved 2018/06/18.