3,5-Dichloro-2,6-difluoropyridine

Base Information

• Chemical Name: 3,5-Dichloro-2,6-difluoropyridine
• CAS No.: 698-51-1
• Molecular Formula: C₅HCl₂F₂N
• Molecular Weight: 183.972
• Hs Code.: 2933399090
• Mol file: 698-51-1.mol

Synonyms:3,5-Dichloro-2,6-difluoropyridine

Chemical Property of 3,5-Dichloro-2,6-difluoropyridine

Chemical Property:

• Vapor Pressure: 0.143mmHg at 25°C
• Melting Point: 45-46 °C
• Refractive Index: 1.526
• Boiling Point: 198.7 °C at 760 mmHg
• PKA: -4.20±0.10(Predicted)
• Flash Point: 74 °C
• PSA: 12.89000
• Density: 1.6 g/cm³
• LogP: 2.66660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3,5-Dichloro-2,6-difluoropyridine ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Dichloro-2,6-difluoropyridine

There total 2 articles about 3,5-Dichloro-2,6-difluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3,5-dichloro-2,4,6-trifluoropyridine (1737-93-5,259875-95-1) → 3,5-dichloro-2,6-difluoropyridine (698-51-1)

Guidance literature:

With diisobutylaluminium hydride; In diethyl ether; dichloromethane; for 68h; Ambient temperature;

Reference yield:

→ 3,5-dichloro-2,6-difluoropyridine (698-51-1)

Guidance literature:

DOI:10.1039/j39710000167 DOI:10.1002/hlca.19760590125 DOI:10.1016/S0022-1139(00)82163-6

Reference yield:

3,5-dichloro-2,6-difluoropyridine (698-51-1) + glycolic acid methyl ester (96-35-5) → 3,5-dichloro-6-fluoro-2-pyridinyloxyacetate (62270-89-7)

Guidance literature:

With sodium carbonate; In methanol; 1,1,2,2-tetrachloroethylene;

upstream raw materials:

3,5-dichloro-2,4,6-trifluoropyridine

Downstream raw materials:

3,3'-[3,5-dichloro-2,6-pyridinediylbis(oxy)]bis(benzonitrile)

4,4'-[3,5-dichloro-2,6-pyridinediylbis(oxy)]bis(benzonitrile)

3,5-dichloro-6-fluoro-2-pyridinyloxyacetate

2-(3,5-Dichloro-6-fluoro-2-pyridyloxy)-ethyl-N-phenyl carbamate

Refernces

• 1、 Chambers, Richard D.,Hall, Christopher W.,Hutchinson, John,Millar, Ross W.. "Polyhalogenated heterocyclic compounds. Part 42. Fluorinated nitrogen heterocycles with unusual substitution patterns". . p. 1705 - 1713. Retrieved 2007/10/03.