(4-aminophenyl)methanesulfonic acid

Base Information

• Chemical Name: (4-aminophenyl)methanesulfonic acid
• CAS No.: 6387-28-6
• Molecular Formula: C7H9 N O3 S
• Molecular Weight: 187.219
• Hs Code.: 2921499090
• Mol file: 6387-28-6.mol

Synonyms:a-Toluenesulfonic acid, p-amino-(7CI,8CI); (p-Aminophenyl)methanesulfonic acid; 4-Aminobenzylsulfonic acid;4-Aminophenylmethanesulfonic acid

Chemical Property of (4-aminophenyl)methanesulfonic acid

Chemical Property:

• PSA: 88.77000
• LogP: 2.31860

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-aminophenyl)methanesulfonic acid

There total 7 articles about (4-aminophenyl)methanesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(4-nitrophenyl)-methanesulfonic acid (53992-33-9) → (4-aminophenyl)methanesulfonic acid (6387-28-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; water; under 1034.32 Torr;

Reference yield: 83.0%

Sodium 4-nitrobenzylsulphonate (36639-50-6) → (4-aminophenyl)methanesulfonic acid (6387-28-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In water; for 22h; Time;

DOI:10.1039/c4cc09502b

Reference yield:

4-nitrobenzyl chloride (100-14-1) → (4-aminophenyl)methanesulfonic acid (6387-28-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂SO₃

2: H₂ / Pd/C

With hydrogen; sodium sulfite; palladium on activated charcoal;

DOI:10.1016/S0040-4039(01)00361-6

upstream raw materials:

(4-nitrophenyl)-methanesulfonic acid

4-nitrobenzyl chloride

Benzylsulfonic acid

benzyl chloride

Downstream raw materials:

sodium (4-acetylaminophenyl)methanesulfonate

Sodium; [4-(2-mercaptomethyl-3-phenyl-propionylamino)-phenyl]-methanesulfonate

Sodium; [4-(2-acetylsulfanylmethyl-3-phenyl-propionylamino)-phenyl]-methanesulfonate

(4-bromo-phenyl)-methanesulfonic acid

Refernces

• 1、 -. "Improved prodrugs of CC-1065 analogs". Page/Page column 15-16; 28. . Retrieved 2008/06/13.
• 2、 -. "Triphendioxazine dyestuffs". . . Retrieved 2008/06/13.