Acetamide, N-(3,3-diethoxypropyl)-

Base Information

• Chemical Name: Acetamide, N-(3,3-diethoxypropyl)-
• CAS No.: 581814-43-9
• Molecular Formula: C9H19NO3
• Molecular Weight: 189.25
• Mol file: 581814-43-9.mol

Synonyms:Acetamide, N-(3,3-diethoxypropyl)-

Chemical Property of Acetamide, N-(3,3-diethoxypropyl)-

Chemical Property:

• PSA: 51.05000
• LogP: 1.75200
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

N-(3,3-Diethoxypropyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-(3,3-Diethoxypropyl)acetamide is an intermediate used in the preparation of piperidine and homopiperidine derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3).

Technology Process of Acetamide, N-(3,3-diethoxypropyl)-

There total 5 articles about Acetamide, N-(3,3-diethoxypropyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

aminopropane diethyl acetal (41365-75-7) + acetyl chloride (75-36-5) → N-(3,3-diethoxypropyl)acetamide (581814-43-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 14h;

Reference yield: 86.0%

aminopropane diethyl acetal (41365-75-7) + acetylacetone (123-54-6,81235-32-7) → N-(3,3-diethoxypropyl)acetamide (581814-43-9)

Guidance literature:

With iodine; tetrabutylammoniun azide; 4-pyrrolidin-1-ylpyridine; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1039/c7ob00731k

Reference yield: 81.0%

aminopropane diethyl acetal (41365-75-7) + tert-butyl 2,2-diazido-3-oxobutanoate → N-(3,3-diethoxypropyl)acetamide (581814-43-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 50 ℃; Reagent/catalyst;

DOI:10.1002/ejoc.201601625

upstream raw materials:

aminopropane diethyl acetal

acetic anhydride

acetyl chloride

acetylacetone

Downstream raw materials:

N-acetyl-3-aminopropanaldehyde

Refernces

• 1、 H?ring, Andreas P.,Biallas, Phillip,Kirsch, Stefan F.. "An Unconventional Reaction of 2,2-Diazido Acylacetates with Amines". . p. 1526 - 1539. Retrieved 2017/04/01.
• 2、 -. "COMPOUND". Page/Page column 223-224. . Retrieved 2008/06/13.