3-Boc-3-methylaminoazatidine

Base Information

• Chemical Name: 3-Boc-3-methylaminoazatidine
• CAS No.: 577777-20-9
• Molecular Formula: C9H18N2O2
• Molecular Weight: 186.254
• Hs Code.: 2933990090
• Mol file: 577777-20-9.mol

Synonyms:2-Methyl-2-propanyl (3-azetidinylmethyl)carbamate;Carbamic acid, N-(3-azetidinylmethyl)-, 1,1-dimethylethyl ester;tert-Butyl (azetidin-3-ylmethyl)carbamate;3-(N-Boc-aminomethyl)azetidine;

Chemical Property of 3-Boc-3-methylaminoazatidine

Chemical Property:

• Boiling Point: 285.5 °C at 760 mmHg
• PKA: 10.21±0.40(Predicted)
• Flash Point: 126.5 °C
• PSA: 41.57000
• Density: 1.018 g/cm³
• LogP: 1.15390
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• Water Solubility.: Soluble in water. (5 g/100ml)

Purity/Quality:

99% ^*data from raw suppliers

tert-butylN-(azetidin-3-yl)-N-methyl-carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is used as pharmaceutical intermediate.

Technology Process of 3-Boc-3-methylaminoazatidine

There total 3 articles about 3-Boc-3-methylaminoazatidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(1-benzhydrylazetidin-3-yl)-N-methylcarbamic acid tert-butyl ester (854038-91-8) → azetidin-3-yl-N-methylcarbamic acid tert-butyl ester (577777-20-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; under 3040.2 Torr;

Reference yield:

N-(1-benzhydrylazetidin-3-yl)-N-methylcarbamic acid tert-butyl ester (854038-91-8) → azetidin-3-yl-N-methylcarbamic acid tert-butyl ester (577777-20-9) + Diphenylmethane (101-81-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; for 18h;

Reference yield:

→ azetidin-3-yl-N-methylcarbamic acid tert-butyl ester (577777-20-9)

Guidance literature:

upstream raw materials:

N-(1-benzhydrylazetidin-3-yl)-N-methylcarbamic acid tert-butyl ester

Downstream raw materials:

tert-butyl 1-(2-amino-6-(benzyloxymethyl)pyrimidin-4-yl)-azetidin-3-yl(methyl)carbamate

C₂₁H₂₀N₄O₂

Refernces

• 1、 -. "PIPERIDIN-PYRIMIDINE DERIVATIVES AS ANTAGONISTS OF HISTAMINE H4 RECEPTOR". Page/Page column 69. . Retrieved 2010/09/17.
• 2、 -. "2 -AMINO-PYRIMIDINE DERIVATIVES AS HISTAMINE H4 ANTAGONISTS". Page/Page column 55. . Retrieved 2009/07/03.