2-Pyridinemethanamine,5-fluoro-(9CI)

Base Information

• Chemical Name: 2-Pyridinemethanamine,5-fluoro-(9CI)
• CAS No.: 561297-96-9
• Molecular Formula: C6H7FN2
• Molecular Weight: 126.133
• Hs Code.: 2933399990
• Mol file: 561297-96-9.mol

Synonyms:(5-fluoropyridin-2-yl)methanamine

Chemical Property of 2-Pyridinemethanamine,5-fluoro-(9CI)

Chemical Property:

• Boiling Point: 181.563 °C at 760 mmHg
• PKA: 8.30±0.39(Predicted)
• Flash Point: 63.607 °C
• PSA: 38.91000
• Density: 1.18 g/cm³
• LogP: 1.37970
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%Min ^*data from raw suppliers

(5-Fluoropyridin-2-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridinemethanamine,5-fluoro-(9CI)

There total 4 articles about 2-Pyridinemethanamine,5-fluoro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

1-(5-fluoropyridin-2-yl)-N-hydroxymethanimine (1159252-09-1) → ((5-fluoro-pyridin-2-yl)-methyl)-amine (561297-96-9)

Guidance literature:

With sodium tetrahydroborate; ethanol; nickel dichloride; for 0.666667h; Cooling with ice;

Reference yield: 44.0%

5-fluoropicolinonitrile (327056-62-2) → ((5-fluoro-pyridin-2-yl)-methyl)-amine (561297-96-9)

Guidance literature:

With ammonia; hydrogen; nickel; In ethanol; at 70 ℃; for 16h; under 25858.1 Torr;

Reference yield:

diethyl (5-fluoro-2-pyridyl)-2-acetamidomalonate (1228788-31-5) → ((5-fluoro-pyridin-2-yl)-methyl)-amine (561297-96-9)

Guidance literature:

diethyl (5-fluoro-2-pyridyl)-2-acetamidomalonate; With sodium hydroxide; In ethanol; for 2h; Inert atmosphere; Reflux;

With hydrogenchloride; In water; at 18 - 80 ℃;

With sodium hydroxide; In water; pH=10;

upstream raw materials:

5-fluoropicolinonitrile

diethyl (5-fluoro-2-pyridyl)-2-acetamidomalonate

5-fluoropicolinaldehyde

1-(5-fluoropyridin-2-yl)-N-hydroxymethanimine

Downstream raw materials:

N-[(5-fluoropyridin-2-yl)methyl]-2-(2,4-dichlorophenoxy)propanamide

rac-(2-(aminomethyl)-5-fluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

tert-butyl(5-fluoropiperidin-2-yl)methylcarbamate

tert-butyl(1-benzyl-5-fluoro-1,2,3,4-tetrahydropyridin-2-yl)methylcarbamate

Refernces

• 1、 -. "HETEROAROMATIC DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF". . . Retrieved 2015/11/10.
• 2、 Lynch, Stephen M.,Devicente, Javier,Hermann, Johannes C.,Jaime-Figueroa, Saul,Jin, Sue,Kuglstatter, Andreas,Li, Hongju,Lovey, Allen,Menke, John,Niu, Linghao,Patel, Vaishali,Roy, Douglas,Soth, Michael,Steiner, Sandra,Tivitmahaisoon, Parcharee,Vu, Minh Diem,Yee, Calvin. "Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome". . p. 2793 - 2800. Retrieved 2013/07/05.