Oxazole-4-carbonitrile

Base Information

• Chemical Name: Oxazole-4-carbonitrile
• CAS No.: 55242-84-7
• Molecular Formula: C4H2N2O
• Molecular Weight: 94.0727
• Hs Code.: 2934999090
• Mol file: 55242-84-7.mol

Synonyms:4-Cyano-oxazole;

Chemical Property of Oxazole-4-carbonitrile

Chemical Property:

• Boiling Point: 198.5 °C at 760 mmHg
• PKA: -3.73±0.10(Predicted)
• Flash Point: 73.9 °C
• PSA: 49.82000
• Density: 1.25 g/cm³
• LogP: 0.54628
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99.9% ^*data from raw suppliers

Oxazole-4-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Oxazole-4-carbonitrile

There total 1 articles about Oxazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

oxazol-4-carboxamide (23012-15-9) → 1,3-oxazole-4-carbonitrile (55242-84-7)

Guidance literature:

With pyridine; In tetrahydrofuran; at 20 ℃; for 3h; Cooling with ice;

Reference yield:

1,3-oxazole-4-carbonitrile (55242-84-7) → C-oxazol-4-yl-methylamine (55242-82-5)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;

DOI:10.1002/ardp.19753080113

Reference yield:

1,3-oxazole-4-carbonitrile (55242-84-7) → oxazole-4-carbothioamide (118802-31-6)

Guidance literature:

With hydrogen sulfide; triethylamine; In ethanol;

DOI:10.1002/hlca.19600430610

upstream raw materials:

oxazol-4-carboxamide

Downstream raw materials:

C-oxazol-4-yl-methylamine

oxazole-4-carbothioamide

1-(oxazol-4-yl)ethanone

Refernces