Succinimidyl Acetate

Base Information

• Chemical Name: Succinimidyl Acetate
• CAS No.: 57212-69-8
• Molecular Formula: C6H7NO4
• Molecular Weight: 0
• Mol file: 57212-69-8.mol

Synonyms:1-(Acetoxy)pyrrolidine-2,5-dione;N-Acetoxysuccinimide;(2,5-Dioxopyrrolidin-1-yl) acetate;2,5-dioxopyrrolidin-1-yl acetate;N-Succinimidyl acetate;

Chemical Property of Succinimidyl Acetate

Chemical Property:

• PSA: 63.68000
• LogP: -0.44860

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Succinimidyl Acetate

There total 9 articles about Succinimidyl Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + acetic acid (64-19-7,77671-22-8) → N-acetoxysuccinimide (14464-29-0,57212-69-8)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.joc.0c01182

Reference yield: 100.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + acetic anhydride (108-24-7) → N-acetoxysuccinimide (14464-29-0,57212-69-8)

Guidance literature:

for 15h;

DOI:10.1007/BF00949686

Reference yield: 93.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + acetyl chloride (75-36-5) → N-acetoxysuccinimide (14464-29-0,57212-69-8)

Guidance literature:

With triethylamine; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/jo00027a028

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

acetic anhydride

N-hydroxysuccinimide

acetyl chloride

Downstream raw materials:

N¹,N³-spermidinebis(acetamide)

N₁-Acetyl-Spermidine

N-(4-aminobutyl)acetamide

ethyl 2-methyl-4-oxo-4,5-dihydrofuran-3-carboxylate

Refernces

• 1、 Antipov, P. I.,Antipova, T. A.,Firsova, Yu. N.,Gudasheva, T. A.,Nikolaev, S. V.,Rebeko, A. G.,Sazonova, N. M.,Tarasyuk, A. V.,Zvyagintsev, A. A.. "Synthesis and In Vitro Neuroprotective Activity of Glycine Analogs of Gk-2 Dimeric Dipeptide Mimetic of Nerve Growth Factor 4th Loop". . . Retrieved 2020/05/28.
• 2、 Cai, Zhi-P.,Conway, Louis P.,Huang, Ying Y.,Wang, Wen J.,Laborda, Pedro,Wang, Ting,Lu, Ai M.,Yao, Hong L.,Huang, Kun,Flitsch, Sabine L.,Liu, Li,Voglmeir, Josef. "Enzymatic synthesis of trideuterated sialosides". . . Retrieved 2019/04/17.