7-HYDROXYCOUMARIN-3-CARBOXYLICACID

Base Information

• Chemical Name: 7-HYDROXYCOUMARIN-3-CARBOXYLICACID
• CAS No.: 56437-16-2
• Molecular Formula: C10H6O5
• Molecular Weight: 206.155
• Mol file: 56437-16-2.mol

Synonyms:7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID

Chemical Property of 7-HYDROXYCOUMARIN-3-CARBOXYLICACID

Chemical Property:

• PSA: 87.74000
• LogP: 1.19680

Purity/Quality:

98%Min ^*data from raw suppliers

2H-1-Benzopyran-3-carboxylicacid,6-hydroxy-2-oxo- 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Hydroxycoumarin-3-carboxylic acid is a pH-indicator that can be immobilized on a support to give a pH sensor.

Technology Process of 7-HYDROXYCOUMARIN-3-CARBOXYLICACID

There total 8 articles about 7-HYDROXYCOUMARIN-3-CARBOXYLICACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

cycl-isopropylidene malonate (2033-24-1) + 2,5-Dihydroxybenzaldehyde (1194-98-5) → 6-hydroxycoumarin-3-carboxylic acid (56437-16-2)

Guidance literature:

With hydroxy sulfonylurea; In neat (no solvent); at 50 ℃; for 0.0833333h; Reagent/catalyst; Green chemistry;

DOI:10.1039/c5ra14001c

Reference yield: 94.0%

2,5-Dihydroxybenzaldehyde (1194-98-5) + malonic acid (141-82-2) → 6-hydroxycoumarin-3-carboxylic acid (56437-16-2)

Guidance literature:

With triton-B adsorbed on flyash; In neat (no solvent); for 0.0111111h; Microwave irradiation; Green chemistry;

DOI:10.13005/ojc/280422

Reference yield: 86.6%

→ 6-hydroxycoumarin-3-carboxylic acid (56437-16-2)

Guidance literature:

In water; for 4h; Reflux;

upstream raw materials:

6-hydroxy-2-oxo-2H-chromene-3-carbonitrile

2,5-Dihydroxybenzaldehyde

6-hydroxy-2-imino-2H-chromene-3-carbonitrile

6-hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethyl ester

Downstream raw materials:

2,5-Dihydroxybenzaldehyde

Refernces

• 1、 -. "Green synthesis method of coumarin-3-carboxylic acid compound". Paragraph 0053-0061; 0076. . Retrieved 2021/06/26.
• 2、 Bayat, Mohammad,Rezaee, Monireh,Zhu, Long-Guan. "A Simple One-Pot Synthesis of Fully Substituted 1H-Pyridone[1,2-a]-Fused-1,3-Diazaheterocycles". . p. 2748 - 2754. Retrieved 2017/09/26.