4-Piperidinecarbonyl chloride, 1-methyl- (9CI)

Base Information

• Chemical Name: 4-Piperidinecarbonyl chloride, 1-methyl- (9CI)
• CAS No.: 41776-24-3
• Molecular Formula: C7H12ClNO
• Molecular Weight: 161.631
• Hs Code.: 2933399090
• Mol file: 41776-24-3.mol

Synonyms:4-Piperidinecarbonyl chloride, 1-methyl- (9CI)

Chemical Property of 4-Piperidinecarbonyl chloride, 1-methyl- (9CI)

Chemical Property:

• Boiling Point: 193.1±33.0 °C(Predicted)
• PKA: 8.23±0.10(Predicted)
• PSA: 20.31000
• Density: 1.125±0.06 g/cm3(Predicted)
• LogP: 1.03150

Purity/Quality:

95+% ^*data from raw suppliers

4-Piperidinecarbonyl chloride, 1-methyl- (9CI) 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Piperidinecarbonyl chloride, 1-methyl- (9CI)

There total 1 articles about 4-Piperidinecarbonyl chloride, 1-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methylpiperidine-4-carboxylic acid (68947-43-3) → 1-methylpiperidine-4-carboxylic acid chloride (41776-24-3)

Guidance literature:

With thionyl chloride;

DOI:10.1016/j.bmcl.2010.01.008

Reference yield: 85.0%

1-methylpiperidine-4-carboxylic acid chloride (41776-24-3) + chlorobenzene (108-90-7) → (4-chlorophenyl)(1-methylpiperidin-4-yl)methanone (500361-49-9)

Guidance literature:

aluminum (III) chloride; In chlorobenzene; at 0 ℃; for 3h; Heating / reflux;

Reference yield: 84.0%

1-methylpiperidine-4-carboxylic acid chloride (41776-24-3) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → (1-methylpiperidin-4-yl)(phenyl)methanone (92040-00-1)

Guidance literature:

aluminum (III) chloride; at 0 ℃; for 3h; Heating / reflux;

upstream raw materials:

1-methylpiperidine-4-carboxylic acid

Downstream raw materials:

(4-chlorophenyl)(1-methylpiperidin-4-yl)methanone

(1-methylpiperidin-4-yl)(phenyl)methanone

(4-fluorophenyl)(1-methylpiperidin-4-yl)methanone

C₂₁H₂₉F₂N₃O₂

Refernces

• 1、 -. "Isoalantolactone derivative, pharmaceutical composition and application thereof". Paragraph 0014. . Retrieved 2019/02/02.
• 2、 Pajouhesh, Hassan,Feng, Zhong-Ping,Ding, Yanbing,Zhang, Lingyun,Pajouhesh, Hossein,Morrison, Jerrie-Lynn,Belardetti, Francesco,Tringham, Elizabeth,Simonson, Eric,Vanderah, Todd W.,Porreca, Frank,Zamponi, Gerald W.,Mitscher, Lester A.,Snutch, Terrance P.. "Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors". scheme or table. p. 1378 - 1383. Retrieved 2010/07/06.