Alvespimycin

Base Information Edit

Chemical Name:Alvespimycin
CAS No.:467214-20-6
Molecular Formula:C32H48N4O8
Molecular Weight:616.755
Hs Code.:29419090
UNII:001L2FE0M3
DSSTox Substance ID:DTXSID00963646
Wikipedia:17-Dimethylaminoethylamino-17-demethoxygeldanamycin
Wikidata:Q4552287
NCI Thesaurus Code:C38142
Pharos Ligand ID:8A2P6WKTAK4Z,8A2VKSZVVLNF
Metabolomics Workbench ID:153429
ChEMBL ID:CHEMBL383824
Mol file:467214-20-6.mol

Synonyms:17-(dimethylaminoethylamino)-17-demethoxy-geldanamycin;17-(dimethylaminoethylamino)-17-demethoxygeldanamycin;17-desmethoxy-17-n,n-dimethylaminoethylamino-geldanamycin;17-dimethylaminoethylamino-17-demethoxy-geldanamycin;17-DMAG;17DMAG;alvespimycin;KOS 1022;KOS-1022;KOS1022;NSC 707545;NSC707545

Suppliers and Price of Alvespimycin

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
17-DMAG
100ug
$ 273.00

Usbiological
17-DMAG hydrochloride
100mg
$ 506.00

Usbiological
17-DMAG Hydrochloride
250mg
$ 422.00

TRC
17-N-(2-Dimethylaminoethylamino)-17-demethoxyGeldanamycin-d6
1mg
$ 155.00

TRC
17-DMAG
2.5mg
$ 315.00

Tocris
17-DMAGhydrochloride ≥99%(HPLC)
1
$ 255.00

Crysdot
17-DMAG 98+%
25mg
$ 70.00

Crysdot
17-DMAG 98+%
10mg
$ 49.00

Crysdot
17-DMAG 98+%
100mg
$ 191.00

Cayman Chemical
17-DMAG ≥98%
10mg
$ 173.00

Total 65 raw suppliers

Chemical Property of Alvespimycin Edit

Chemical Property:

PSA：169.52000
Density:1.2
LogP:3.33320
Storage Temp.:Desiccate at -20°C
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:8
Exact Mass:616.34721450
Heavy Atom Count:44
Complexity:1230

Purity/Quality:

98%,99%, ^*data from raw suppliers

17-DMAG ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC
Isomeric SMILES:C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)\C)C)O)OC
Recent ClinicalTrials:Clinical Trial of Intravenous Alvespimycin in Patients With Her2 Positive Breast Cancer
Description Geldanamycin is a potent inhibitor of Hsp90 that has poor water solubility. 17-DMAG is a water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC50 = 24 nM) and has excellent bioavailability and tissue distribution in animals. Like other Hsp90 inhibitors, 17-DMAG has diverse anti-tumor actions and has potential in treating certain types of cancer. This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway. 17-DMAG also ameliorates high fat diet-induced renal failure in a mouse model of diabetes.
Uses 17-DMAG is an analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG. The labelled derivative of the analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). It acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG. 17-DMAG is a synthetic Geldanamycin derivative and inhibitor of Hsp90.

Technology Process of Alvespimycin

There total 1 articles about Alvespimycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%