2-Quinolineethanamine

Base Information

• Chemical Name: 2-Quinolineethanamine
• CAS No.: 104037-38-9
• Molecular Formula: C11H12N2
• Molecular Weight: 172.23
• Hs Code.: 2933499090
• European Community (EC) Number: 827-794-9
• DSSTox Substance ID: DTXSID20436403
• Nikkaji Number: J606.242C
• Wikidata: Q82251672
• Mol file: 104037-38-9.mol

Synonyms:2-(2-aminoethyl)quinoline hydrochloride;D 1997;D-1997

Chemical Property of 2-Quinolineethanamine

Chemical Property:

• Melting Point: 174℃
• Boiling Point: 357 °C at 760 mmHg
• PKA: 9.84±0.10(Predicted)
• Flash Point: 169.7 °C
• PSA: 38.91000
• Density: 1.469 g/cm³
• LogP: 2.43630
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 172.100048391
• Heavy Atom Count: 13
• Complexity: 158

Purity/Quality:

98%min ^*data from raw suppliers

2-(Quinolin-2-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC(=N2)CCN

Technology Process of 2-Quinolineethanamine

There total 12 articles about 2-Quinolineethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(2-azidoethyl)quinoline → D 1997 (104037-38-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In 1,4-dioxane; ethanol; at 20 ℃; for 4h;

DOI:10.1021/acs.jmedchem.9b00224

Reference yield: 43.0%

N-<2-(2-Quinolyl)ethyl>succinimide (74273-98-6) → D 1997 (104037-38-9)

Guidance literature:

With hydrazine hydrate; In methanol; Reflux;

Reference yield: 35.0%

2-(quinolin-2-yl)acetonitrile (14068-28-1) → D 1997 (104037-38-9)

Guidance literature:

With ammonia; hydrogen; In ethanol; water; under 1810.07 Torr;

upstream raw materials:

2-quinolin-2-yl-ethanol

ethyl 2-(2-quinolyl)acetate

2-Chloromethylquinoline

2-(quinolin-2-yl)acetonitrile

Downstream raw materials:

N-(2-[2]quinolyl-ethyl)-formamide

7-chloro-5-methyl-2-(2-quinolin-2-ylethyl)-3,5-dihydro-2H-pyrrolo[3,4-c]pyridine-1,6-dione

Refernces

• 1、 Huang, Yi-You,Yu, Yan-Fa,Zhang, Chen,Chen, Yiping,Zhou, Qian,Li, Zhuoming,Zhou, Sihang,Li, Zhe,Guo, Lei,Wu, Deyan,Wu, Yinuo,Luo, Hai-Bin. "Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors". . p. 3707 - 3721. Retrieved 2019/04/26.
• 2、 -. "NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A". . . Retrieved 2013/02/28.