4-Methyl-2,2'-bipyridine

Base Information

• Chemical Name: 4-Methyl-2,2'-bipyridine
• CAS No.: 56100-19-7
• Molecular Formula: C11H10N2
• Molecular Weight: 170.214
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID60452061
• Nikkaji Number: J1.083.099K
• Wikidata: Q82272426
• Mol file: 56100-19-7.mol

Synonyms:4-METHYL-2,2'-BIPYRIDINE;56100-19-7;4-methyl-2-pyridin-2-ylpyridine;4-Methyl-[2,2']bipyridinyl;MFCD08062570;4'-methyl-2,2'-bipyridine;SCHEMBL563123;DTXSID60452061;OHSRAWAUPZWNKY-UHFFFAOYSA-N;AMY18771;AKOS006285722;CS-W018460;BS-52235;4-METHYL-2-(PYRIDIN-2-YL)PYRIDINE;N12815;A870021;J-400624

Chemical Property of 4-Methyl-2,2'-bipyridine

Chemical Property:

• Melting Point: 62-64 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 296.6±25.0 °C(Predicted)
• PKA: 4.73±0.18(Predicted)
• Flash Point: 111.9oC
• PSA: 25.78000
• Density: 1.081±0.06 g/cm3(Predicted)
• LogP: 2.45200
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 170.084398327
• Heavy Atom Count: 13
• Complexity: 158

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methyl-2,2'-bipyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC=C1)C2=CC=CC=N2

Technology Process of 4-Methyl-2,2'-bipyridine

There total 3 articles about 4-Methyl-2,2'-bipyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-pyridine (109-04-6) + 2-Bromo-4-picoline (4926-28-7) → picoline (108-89-4) + [2,2]bipyridinyl (366-18-7) + 4,4'-dimethyl-2,2'-bipyridines (1134-35-6) + 4-methyl-2,2'-bipyridine (56100-19-7)

Guidance literature:

With nickel(II) bromide hydrate; sodium iodide; In N,N-dimethyl-formamide; at 20 ℃; Electrochemical reaction; Inert atmosphere;

DOI:10.1016/j.tet.2012.01.017

Reference yield:

2-bromo-pyridine (109-04-6) + 2-Bromo-4-picoline (4926-28-7) → pyridine (110-86-1) + picoline (108-89-4) + [2,2]bipyridinyl (366-18-7) + 4,4'-dimethyl-2,2'-bipyridines (1134-35-6) + 4-methyl-2,2'-bipyridine (56100-19-7)

Guidance literature:

With nickel(II) bromide hydrate; sodium iodide; In N,N-dimethyl-formamide; at 20 ℃; Electrochemical reaction; Inert atmosphere;

DOI:10.1016/j.tet.2012.01.017

Reference yield:

Tetramethylblei-(IV) (75-74-1) → [2,2]bipyridinyl (366-18-7) + 4-methyl-2,2'-bipyridine (56100-19-7)

Guidance literature:

With sodium hydroxide; Yield given. Multistep reaction. Yields of byproduct given; 1.) acetonitrile, 25 deg C;

DOI:10.1021/ja00369a030

upstream raw materials:

Tetramethylblei-(IV)

2-bromo-pyridine

2-Bromo-4-picoline

Downstream raw materials:

4'-methyl-2,2'-bipyridine-4-carboxylaldehyde

2,2'-bipyridine-4-carboxaldehyde

Refernces

• 1、 Rollick,Kochi. "OXIDATION-REDUCTION MECHANISMS - INNER-SPHERE AND OUTER-SPHERE ELECTRON TRANSFER IN THE REDUCTION OF IRON(III), RUTHENIUM(III), AND OSMIUM(III) COMPLEXES BY ALKYL RADICALS. MECHANISMS -". . p. 1319 - 1330. Retrieved 2007/10/02.