2-Pyridinecarboxamide,5-fluoro-(9CI)

Base Information

• Chemical Name: 2-Pyridinecarboxamide,5-fluoro-(9CI)
• CAS No.: 499796-71-3
• Molecular Formula: C6H5FN2O
• Molecular Weight: 140.117
• Hs Code.: 2933399990
• Mol file: 499796-71-3.mol

Synonyms:2-Pyridinecarboxamide,5-fluoro-(9CI);5-fluoropicolinaMide;5-Fluoro-2-pyridinecarboxaMide;2-PyridinecarboxaMide, 5-fluoro

Chemical Property of 2-Pyridinecarboxamide,5-fluoro-(9CI)

Chemical Property:

• Boiling Point: 256.7 °C at 760 mmHg
• PKA: 15.00±0.50(Predicted)
• Flash Point: 109 °C
• PSA: 55.98000
• Density: 1.327 g/cm³
• LogP: 1.01990
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99.9% ^*data from raw suppliers

5-Fluoropicolinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridinecarboxamide,5-fluoro-(9CI)

There total 5 articles about 2-Pyridinecarboxamide,5-fluoro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-fluoropicolinonitrile (327056-62-2) → 5-fluoro-2-pyridinecarboxamide (499796-71-3)

Guidance literature:

With cerium(IV) oxide; water; at 80 ℃; for 6h;

DOI:10.1021/cs501448n

Reference yield:

5-fluoropicolinic acid (107504-08-5) → 5-fluoro-2-pyridinecarboxamide (499796-71-3)

Guidance literature:

With ammonium hydroxide; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 23 ℃; for 16h;

Reference yield:

5-fluoropicolinoyl chloride (717871-83-5) → 5-fluoro-2-pyridinecarboxamide (499796-71-3)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; at 0 - 10 ℃; for 0.5h;

upstream raw materials:

5-fluoropicolinonitrile

5-fluoropicolinic acid

5-fluoropicolinoyl chloride

5-amino-2-cyanopyridine

Downstream raw materials:

5-fluoropicolinic acid

Refernces

• 1、 Tamura, Masazumi,Sawabe, Kyoichi,Tomishige, Keiichi,Satsuma, Atsushi,Shimizu, Ken-Ichi. "Substrate-Specific Heterogeneous Catalysis of CeO2 by Entropic Effects via Multiple Interactions". . p. 20 - 26. Retrieved 2015/04/27.
• 2、 -. "CATHEPSIN CYSTEINE PROTEASE INHIBITORS". . . Retrieved 2015/04/28.