4-(4-HYDROXYPHENOXY)BENZOIC ACID

Base Information

• Chemical Name: 4-(4-HYDROXYPHENOXY)BENZOIC ACID
• CAS No.: 500-76-5
• Molecular Formula: C13H10O4
• Molecular Weight: 230.22
• Hs Code.: 2918990090
• Mol file: 500-76-5.mol

Synonyms:4-(4-HYDROXYPHENOXY)BENZOIC ACID;4-(4-HYDROXYPHENOXY)BENZOIC ACID 99+%

Chemical Property of 4-(4-HYDROXYPHENOXY)BENZOIC ACID

Chemical Property:

• Vapor Pressure: 4.43E-08mmHg at 25°C
• Melting Point: 196°C
• Refractive Index: 1.638
• Boiling Point: 427.8°C at 760 mmHg
• PKA: 4.39±0.10(Predicted)
• Flash Point: 168.6°C
• PSA: 66.76000
• Density: 1.346g/cm³
• LogP: 2.88270
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: almost transparency in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(4-Hydroxyphenoxy)benzoic Acid ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38-43
• Safety Statements: 26-36/37/39-36/37

MSDS Files:

Useful:

Technology Process of 4-(4-HYDROXYPHENOXY)BENZOIC ACID

There total 7 articles about 4-(4-HYDROXYPHENOXY)BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4'-(4-methoxyphenoxy)benzoic acid (3525-22-2) → 4-(4-hydroxyphenoxy)benzoic acid (500-76-5)

Guidance literature:

With hydrogen bromide; tetrabutyl phosphonium bromide; at 100 ℃; for 9h;

DOI:10.1080/00397919308012606

Reference yield:

benzyl 4-(4-benzyloxyphenoxy)benzoate (620632-58-8) → 4-(4-hydroxyphenoxy)benzoic acid (500-76-5)

Guidance literature:

With hydrogen; 10% palladium on activated carbon; In ethyl acetate; for 18h; under 2068.65 Torr;

Reference yield:

4-fluorobenzaldehyde (459-57-4) → 4-(4-hydroxyphenoxy)benzoic acid (500-76-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / N,N-dimethyl-formamide / 0.33 h / 175 °C / Sealed tube

2: Jones reagent / acetone

3: hydrogen bromide; acetic acid / 12 h / Reflux

With Jones reagent; hydrogen bromide; acetic acid; potassium hydroxide; In N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm400275h

upstream raw materials:

4'-(4-methoxyphenoxy)benzoic acid

Ethyl 4-hydroxybenzoate

1-bromo-4-methoxy-benzene

benzyl 4-(4-benzyloxyphenoxy)benzoate

Downstream raw materials:

cyanomethyl (11β,17α)-17-{[4-(4-acetoxyphenoxy)benzoyl]oxy}-9-fluoro-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate

N-(19-((2-carbamoyl-5-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)-4,7,10,13,16-pentaoxanonadecyl)-4-(4-hydroxyphenoxy)benzamide

N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]-methyl}-2-methylpropyl-4-(4-hydroxyphenoxy)benzamide

Refernces

• 1、 -. "1-substituted 4-arylpiperazine as kappa opioid receptor antagonists". Page/Page column 19. . Retrieved 2016/12/26.
• 2、 -. "1-SUBSTITUTED 4-ARYLPIPERAZINE AS KAPPA OPIOID RECEPTOR ANTAGONISTS". Page/Page column 24. . Retrieved 2013/06/27.