4-Benzyloxyphenylhydrazine

Base Information

• Chemical Name: 4-Benzyloxyphenylhydrazine
• CAS No.: 51145-58-5
• Molecular Formula: C13H14N2O
• Molecular Weight: 214.267
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID901295601
• Nikkaji Number: J60.169A
• Mol file: 51145-58-5.mol

Synonyms:4-BENZYLOXYPHENYLHYDRAZINE;51145-58-5;[4-(benzyloxy)phenyl]hydrazine;(4-Benzyloxyphenyl)hydrazine;(4-phenylmethoxyphenyl)hydrazine;(4-(benzyloxy)phenyl)hydrazine;p-(benzyloxy)phenylhydrazine;(4-Benzyloxy-phenyl)-hydrazine;Hydrazine, [4-(phenylmethoxy)phenyl]-;p-benzyloxyphenylhydrazine;Oprea1_307414;SCHEMBL103965;4-(benzyloxy)-phenyl hydrazine;DTXSID901295601;[4-(Phenylmethoxy)phenyl]hydrazine;BBL008195;MFCD01993592;STK078096;1-[4-(Benzyloxy)phenyl]hydrazine #;AKOS003626409;BB 0249793;FT-0647148;EN300-114814

Chemical Property of 4-Benzyloxyphenylhydrazine

Chemical Property:

• Vapor Pressure: 1.79E-06mmHg at 25°C
• Refractive Index: 1.649
• Boiling Point: 395.8°C at 760 mmHg
• Flash Point: 193.2°C
• PSA: 47.28000
• Density: 1.185g/cm³
• LogP: 3.32450
• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 214.110613074
• Heavy Atom Count: 16
• Complexity: 184

Purity/Quality:

98%min ^*data from raw suppliers

4-Benzyloxyphenylhydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=C(C=C2)NN
• Uses: (4-Phenylmethoxyphenyl)hydrazine is used as a reactant in the preparation of indolyl thiazole derivatives as xanthine oxidase inhibitors and antiinflammatory drugs.

Technology Process of 4-Benzyloxyphenylhydrazine

There total 9 articles about 4-Benzyloxyphenylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

aquo-dichloro-tin(II) + sodium hydroxide, ethyl acetate + 4-benzyloxyaniline hydrochloride (51388-20-6) → [4-(benzyloxy)phenyl]hydrazine (51145-58-5)

Guidance literature:

With sodium nitrite; In hydrogenchloride; water;

Reference yield: 67.0%

4-benzyloxyaniline hydrochloride (51388-20-6) → [4-(benzyloxy)phenyl]hydrazine (51145-58-5)

Guidance literature:

4-benzyloxyaniline hydrochloride; With hydrogenchloride; sodium nitrite; at 0 ℃; for 0.166667h;

With hydrogenchloride; tin(ll) chloride; at 0 - 20 ℃; for 1h; Further stages.;

DOI:10.1021/jm010283l

Reference yield:

p-benzyloxyaniline (6373-46-2) → [4-(benzyloxy)phenyl]hydrazine (51145-58-5)

Guidance literature:

With hydrogenchloride; sodium nitrite;

DOI:10.1016/j.bmcl.2015.12.055

upstream raw materials:

4-benzyloxyaniline hydrochloride

p-benzyloxyaniline

4-amino-phenol

4-N-tert-butoxycarbonylaminophenol

Downstream raw materials:

6-benzyloxy-1,2,3,4-tetrahydro-carbazole

4-benzyloxy-(N-tert-butoxycarbonyl)phenylhydrazine

5-benzyloxytryptamine

2-[4-(benzyloxy)phenyl]-5-methyl-2,4-dihydropyrazol-3-one

Refernces

• 1、 Song, Jeong Uk,Jang, Jae Wan,Kim, Tae Hun,Park, Heuisul,Park, Wan Su,Jung, Sang-Hun,Kim, Geun Tae. "Structure-based design and biological evaluation of novel 2-(indol-2-yl) thiazole derivatives as xanthine oxidase inhibitors". . p. 950 - 954. Retrieved 2016/05/24.
• 2、 -. "Thrombopoietin mimetics". . . Retrieved 2008/06/13.