Furan-2-Sulfonamide

Base Information

• Chemical Name: Furan-2-Sulfonamide
• CAS No.: 55673-71-7
• Molecular Formula: C4H5NO3S
• Molecular Weight: 147.15
• European Community (EC) Number: 860-549-4
• DSSTox Substance ID: DTXSID40546250
• Wikidata: Q27460080
• Mol file: 55673-71-7.mol

Synonyms:Furan-2-Sulfonamide;55673-71-7;2-FURANSULFONAMIDE;furansulfonamide;SCHEMBL791265;DTXSID40546250;3s75;RHBMVXBGYGIDJN-UHFFFAOYSA-N;AKOS013258160;AT22943;SB61990;EN300-275737;Q27460080

Chemical Property of Furan-2-Sulfonamide

Chemical Property:

• Melting Point: 122-123.5 °C
• Boiling Point: 301.4±34.0 °C(Predicted)
• PKA: 9.79±0.60(Predicted)
• PSA: 81.68000
• Density: 1.454±0.06 g/cm3(Predicted)
• LogP: 1.70810
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 146.99901420
• Heavy Atom Count: 9
• Complexity: 181

Purity/Quality:

99%min ^*data from raw suppliers

Furan-2-sulfonamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=COC(=C1)S(=O)(=O)N

Technology Process of Furan-2-Sulfonamide

There total 3 articles about Furan-2-Sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

furan-2-sulfonyl chloride (52665-48-2) → furan-2-sulfonamide (55673-71-7)

Guidance literature:

With hydrogenchloride; ammonium hydroxide; In water; at 0 - 20 ℃; for 0.75h; pH=7;

DOI:10.1016/j.bmc.2014.03.015

Reference yield:

5-sulfamoylfuran-2-carboxylic acid (98027-63-5) → furan-2-sulfonamide (55673-71-7)

Guidance literature:

With quinoline; copper; at 190 ℃;

DOI:10.1021/jo01371a003

Reference yield:

furan-2-sulfonyl chloride (52665-48-2) + conc. NH4 OH → furan-2-sulfonamide (55673-71-7)

Guidance literature:

upstream raw materials:

furan-2-sulfonyl chloride

5-sulfamoylfuran-2-carboxylic acid

Downstream raw materials:

N-benzylidene-2-furylsulfonamide

Refernces

• 1、 Harrison, David,Boutard, Nicolas,Brzozka, Krzysztof,Bugaj, Marta,Chmielewski, Stefan,Cierpich, Anna,Doedens, John R.,Fabritius, Charles-Henry R.Y.,Gabel, Christopher A.,Galezowski, Michal,Kowalczyk, Piotr,Levenets, Oleksandr,Mroczkowska, Magdalena,Palica, Katarzyna,Porter, Roderick A.,Schultz, David,Sowinska, Marta,Topolnicki, Grzegorz,Urbanski, Piotr,Woyciechowski, Jakub,Watt, Alan P.. "Discovery of a series of ester-substituted NLRP3 inflammasome inhibitors". supporting information. . Retrieved 2020/10/02.
• 2、 Egleton, James E.,Thinnes, Cyrille C.,Seden, Peter T.,Laurieri, Nicola,Lee, Siu Po,Hadavizadeh, Kate S.,Measures, Angelina R.,Jones, Alan M.,Thompson, Sam,Varney, Amy,Wynne, Graham M.,Ryan, Ali,Sim, Edith,Russell, Angela J.. "Structure-activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1". supporting information. p. 3030 - 3054. Retrieved 2014/05/20.