2-Amino-4-(4-bromophenyl)-5-methylthiazole

Base Information

• Chemical Name: 2-Amino-4-(4-bromophenyl)-5-methylthiazole
• CAS No.: 65705-44-4
• Molecular Formula: C10H9BrN2S
• Molecular Weight: 269.165
• Hs Code.: 2934100090
• European Community (EC) Number: 672-280-8
• DSSTox Substance ID: DTXSID80352039
• Wikidata: Q82128979
• Mol file: 65705-44-4.mol

Synonyms:65705-44-4;2-Amino-4-(4-bromophenyl)-5-methylthiazole;4-(4-Bromophenyl)-5-methyl-1,3-thiazole-2-ylamine;4-(4-bromophenyl)-5-methylthiazol-2-amine;4-(4-bromophenyl)-5-methyl-1,3-thiazol-2-amine;2-Thiazolamine,4-(4-bromophenyl)-5-methyl-;MFCD00170268;4-(4-Bromophenyl)-5-methyl-1,3-thiazole-2-yl amine;SCHEMBL11480686;DTXSID80352039;ULSZADQFOHESKR-UHFFFAOYSA-N;AKOS000116902;AM90117;MS-6265;CS-0153479;FT-0641028;2-amino-4-(p-bromophenyl)-5-methyl thiazole;4-(4-bromophenyl)-5-methyl-thiazol-2-amine;EN300-08661;A835194;2-Amino-4-(4-bromophenyl)-5-methylthiazole, 97%;Z48847486

Chemical Property of 2-Amino-4-(4-bromophenyl)-5-methylthiazole

Chemical Property:

• Appearance/Colour: solid
• Vapor Pressure: 1.67E-06mmHg at 25°C
• Melting Point: 396.8 °C at 760 mmHg
• Refractive Index: 1.666
• Boiling Point: 193.8 °C
• Flash Point: 193.8°C
• PSA: 67.15000
• Density: 1.563 g/cm³
• LogP: 4.04440
• Storage Temp.: 2-8°C
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 267.96698
• Heavy Atom Count: 14
• Complexity: 195

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-4-(4-bromophenyl)-5-methyl-1,3-thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-41-37/38-22
• Safety Statements: 26-36/37/39-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=C(N=C(S1)N)C2=CC=C(C=C2)Br

Technology Process of 2-Amino-4-(4-bromophenyl)-5-methylthiazole

There total 2 articles about 2-Amino-4-(4-bromophenyl)-5-methylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4'-Bromopropiophenone (10342-83-3) + thiourea (17356-08-0) → 2-amino-4-(4’-bromophenyl)-5-methyl-1,3-thiazole (65705-44-4)

Guidance literature:

With iodine; for 8h; Heating;

DOI:10.14233/ajchem.2017.20925

Reference yield:

thiourea (17356-08-0) + 2-bromo-1-(4-bromophenyl)propan-1-one (38786-67-3) → 2-amino-4-(4’-bromophenyl)-5-methyl-1,3-thiazole (65705-44-4)

Guidance literature:

In ethanol; Reflux;

DOI:10.1016/j.ejmech.2017.12.030

Reference yield: 72.0%

6-(4-chlorobenzyloxy)-2-naphthaldehyde (1417915-75-3) + 2-amino-4-(4’-bromophenyl)-5-methyl-1,3-thiazole (65705-44-4) → 2-[6-(4-chlorobenzyloxy)-2-naphthyliden-4-(4-bromophenyl)]-5-methyl-1,3-thiazole

Guidance literature:

With acetic acid; In ethanol; for 7h; Reflux;

DOI:10.14233/ajchem.2017.20925

upstream raw materials:

4'-Bromopropiophenone

thiourea

2-bromo-1-(4-bromophenyl)propan-1-one

Downstream raw materials:

(1H-benzoimidazol-2-ylmethyl)-[4-(4-bromo-phenyl)-5-methyl-thiazol-2-yl]-amine

4-(4-bromo-phenyl)-2-fluoro-5-methyl-thiazole

N-(4-(4-bromophenyl)-5-methylthiazol-2-yl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide

Refernces

• 1、 Maher. "Synthesis and antimicrobial activities of some novel 2,3-substituted-1,3-thiazolidin-4-ones derived from 2-amino-1,3-thiazole". . p. 2794 - 2798. Retrieved 2017/11/10.