DL-PIPECOLIC ACID HYDROCHLORIDE

Base Information

• Chemical Name: DL-PIPECOLIC ACID HYDROCHLORIDE
• CAS No.: 5107-10-8
• Molecular Formula: C6H12ClNO2
• Molecular Weight: 165.62
• Mol file: 5107-10-8.mol

Synonyms:PIPERIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE;DL-PIPECOLINIC ACID HCL;DL-PIPECOLIC ACID HYDROCHLORIDE;dl-pipecolinic acid hydrochloride;DL-PIPECOLIC ACID HCL;Pyperidincarbononic acid chlorohydrate

Chemical Property of DL-PIPECOLIC ACID HYDROCHLORIDE

Chemical Property:

• Boiling Point: 265.8oC at 760mmHg
• Flash Point: 114.5oC
• PSA: 49.33000
• LogP: 1.34390

Purity/Quality:

98%Min ^*data from raw suppliers

DL-PIPECOLIC ACID HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-PIPECOLIC ACID HYDROCHLORIDE

There total 7 articles about DL-PIPECOLIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Methyl 1-(trichloroacetyl)-2-piperidinecarboxylate (138286-86-9) → piperidine-2-carboxylic acid hydrochloride (15862-86-9,5107-10-8)

Guidance literature:

With potassium hydroxide; In methanol; Ambient temperature;

DOI:10.1021/jo00031a052

Reference yield: 89.0%

(2R)-N-acetyl-2-(methoxycarbonyl)piperidine (111956-95-7) → (2R)-pipecolinic acid hydrochloride (38470-14-3,5107-10-8)

Guidance literature:

With hydrogenchloride; In water; Heating;

DOI:10.1039/b209087m

Reference yield:

Piperidine-1,2-dicarboxylic acid 1-phenyl ester → (2S)-2-piperidinecarboxylic acid hydrochloride (2133-33-7,5107-10-8) + (2R)-pipecolinic acid hydrochloride (38470-14-3,5107-10-8)

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide; In methanol; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00114a006

upstream raw materials:

Methyl 1-(trichloroacetyl)-2-piperidinecarboxylate

2,6-Dibromhexansaeure-methylester

(2R)-N-acetyl-2-(methoxycarbonyl)piperidine

(2R)-methyl N-acetyl-5,6-didehydropipecolate

Refernces

• 1、 Foti,Comins. "Synthesis and reactions of α-(trifluromethanesulfonyloxy) enecarbamates prepared from N-acyllactams". . p. 2656 - 2657. Retrieved 2007/10/02.