1-(CHLOROMTHYL)-3-PHENOXY BENZENE

Base Information

• Chemical Name: 1-(CHLOROMTHYL)-3-PHENOXY BENZENE
• CAS No.: 52322-81-3
• Molecular Formula: C13H11ClO
• Molecular Weight: 218.683
• Hs Code.: 2909309090
• Mol file: 52322-81-3.mol

Synonyms:1-(CHLOROMTHYL)-3-PHENOXY BENZENE

Chemical Property of 1-(CHLOROMTHYL)-3-PHENOXY BENZENE

Chemical Property:

• Boiling Point: 299.5±20.0 °C(Predicted)
• PSA: 9.23000
• Density: 1.161±0.06 g/cm3(Predicted)
• LogP: 4.44070

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(CHLOROMTHYL)-3-PHENOXY BENZENE

There total 4 articles about 1-(CHLOROMTHYL)-3-PHENOXY BENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-Chloro-3-methylphenol (59-50-7) + iodobenzene (591-50-4) → 3-phenoxy-6-chlorotoluene (52322-81-3)

Guidance literature:

With copper(II) glycinate monohydrate; potassium hydroxide; In dimethyl sulfoxide; at 80 ℃; for 8h;

DOI:10.1016/j.tetlet.2012.06.071

Reference yield: 80.0%

bromobenzene (108-86-1,52753-63-6) + 4-Chloro-3-methylphenol (59-50-7) → 3-phenoxy-6-chlorotoluene (52322-81-3)

Guidance literature:

With copper(II) glycinate monohydrate; potassium hydroxide; In dimethyl sulfoxide; at 80 ℃; for 8h;

DOI:10.1016/j.tetlet.2012.06.071

Reference yield:

3-phenoxytoluene (3586-14-9) → 3-phenoxy-6-chlorotoluene (52322-81-3)

Guidance literature:

With potassium permanganate; aliphatic acid; corresponding anhydride; copper dichloride; Yield given; Heating;

DOI:10.1021/jo00335a048

upstream raw materials:

3-phenoxytoluene

bromobenzene

4-Chloro-3-methylphenol

iodobenzene

Downstream raw materials:

3-Phenoxybenzyl alcohol

(2-Chloro-5-phenoxy-phenyl)-acetic acid

Refernces

• 1、 Chaintreau, Alain,Adrian, Guy,Couturier, Daniel. "Manganic Oxidation of 3-Substituted Toluenes". . p. 4562 - 4564. Retrieved 2007/10/02.