Dimethyl-2-oxo-3-phenylpropyl phosphonate, 98 %

Base Information

• Chemical Name: Dimethyl-2-oxo-3-phenylpropyl phosphonate, 98 %
• CAS No.: 52343-38-1
• Molecular Formula: C11H15O4P
• Molecular Weight: 242.211
• Hs Code.: 2931900090
• Mol file: 52343-38-1.mol

Synonyms:Dimethyl-2-oxo-3-phenylpropyl phosphonate, 98 %

Chemical Property of Dimethyl-2-oxo-3-phenylpropyl phosphonate, 98 %

Chemical Property:

• PSA: 62.41000
• LogP: 2.28410

Purity/Quality:

95%-98% ^*data from raw suppliers

DIMETHYL-2-OXO-3-PHENYLPROPYL PHOSPHONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Dimethyl-2-oxo-3-phenylpropyl phosphonate, 98 %

There total 10 articles about Dimethyl-2-oxo-3-phenylpropyl phosphonate, 98 % which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N-methoxy-N-methyl-2-phenylacetamide (95092-10-7) + dimethyl methane phosphonate (756-79-6) → dimethyl 2-oxo-3-phenylpropylphosphonate (52343-38-1)

Guidance literature:

dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.333333h;

N-methoxy-N-methyl-2-phenylacetamide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

With hydrogenchloride; In water;

DOI:10.1016/S0040-4020(00)00153-8

Reference yield: 62.0%

dimethyl methane phosphonate (756-79-6) + benzeneacetic acid methyl ester (101-41-7) → dimethyl 2-oxo-3-phenylpropylphosphonate (52343-38-1)

Guidance literature:

dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

benzeneacetic acid methyl ester; In tetrahydrofuran; hexane; at -78 ℃; for 2.16667h;

Reference yield: 62.0%

phenylacetyl chloride (103-80-0) + dimethyl methane phosphonate (756-79-6) → dimethyl 2-oxo-3-phenylpropylphosphonate (52343-38-1)

Guidance literature:

dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

With copper(l) iodide; In tetrahydrofuran; hexane; at -30 ℃; for 1.5h;

phenylacetyl chloride; In hexane; dichloromethane; at -40 - 20 ℃;

DOI:10.1016/S0040-4020(00)00153-8

upstream raw materials:

dimethyl 2-hydroxy-3-phenylpropanephosphonate

phenylacetyl chloride

dimethyl methane phosphonate

N-methoxy-N-methyl-2-phenylacetamide

Downstream raw materials:

(1-Isopropyl-4-oxo-3-phenyl-1,4-dihydro-quinolin-2-ylmethyl)-phosphonic acid dimethyl ester

(1-Methyl-4-oxo-3-phenyl-1,4-dihydro-quinolin-2-ylmethyl)-phosphonic acid dimethyl ester

1-C-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-3-phenylacetone

(5R)-1-(4-chlorobutyl)-5-[(1E)-3-oxo-4-phenylbut-1-enyl]pyrrolidin-2-one

Refernces

• 1、 Sivák, Ivan,Václav, Jakub,Berke?, Du?an,Kolarovi?, Andrej. "Straightforward synthesis of functionalized (E)-3-acylacrylic acids". . p. 8871 - 8875. Retrieved 2015/11/02.
• 2、 Kambe, Tohru,Maruyama, Toru,Nakano, Masayuki,Nakai, Yoshihiko,Yoshida, Tadahiro,Matsunaga, Naoki,Oida, Hiroji,Konaka, Akira,Maruyama, Takayuki,Nakai, Hisao,Toda, Masaaki. "Discovery of a novel EP2/EP4 dual agonist with high subtype-selectivity". scheme or table. p. 396 - 401. Retrieved 2012/02/16.