Naftopidil dihydrochloride

Base Information

• Chemical Name: Naftopidil dihydrochloride
• CAS No.: 57149-08-3
• Molecular Formula: C₂₄H₂₈N₂O₃*ClH
• Molecular Weight: 428.959
• UNII: 6I80E37JBE
• Wikidata: Q27264951
• ChEMBL ID: CHEMBL1593765
• Mol file: 57149-08-3.mol

Synonyms:NAFTOPIDIL DIHYDROCHLORIDE;57149-08-3;Naftopidil DiHCl;Naftopidil (dihydrochloride);Naftopidil dihydrochloride [MI];Naftopidil 2HCl;Naftopidil dihydrochloride, (+/-)-;UNII-6I80E37JBE;6I80E37JBE;1-(4-(2-methoxyphenyl)piperazin-1-yl)-3-(naphthalen-1-yloxy)propan-2-ol dihydrochloride;1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol;dihydrochloride;KT-611;BM-15275;4-(2-Methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-1-piperazineethanol dihydrochloride;1-Piperazineethanol, 4-(2-methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-, hydrochloride (1:2);1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphthoxy)-2-propanol dihydrochloride;SR-01000002977;KT-611 dihydrochloride;Naftopidil.Dihydrochloride;EU-0100941;KT-611 2HCl;SCHEMBL1322047;CHEMBL1593765;HY-B0391A;HMS1571C11;Tox21_500941;s1387;AKOS015900296;CCG-220975;CCG-222245;FE-0212;LP00941;NCGC00094247-01;NCGC00261626-01;AC-24018;CS-0019738;FT-0672587;N-158;SW196570-5;VU0612514-1;A50003;C75677;M02151;A913228;SR-01000002977-2;SR-01000002977-4;Q27264951;SR-01000002977-10;SR-01000002977-11;F3368-0103;4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-1-piperazineethanol,2HCl;1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphthyloxy)-2-propanol dihydrochloride;1-PIPERAZINEETHANOL, 4-(2-METHOXYPHENYL)-.ALPHA.-((1-NAPHTHALENYLOXY)METHYL)-, HYDROCHLORIDE (1:2);4-(2-METHOXYPHENYL)-.ALPHA.-((1-NAPHTHALENYLOXY)METHYL)-1-PIPERAZINEETHANOL DIHYDROCHLORIDE

Chemical Property of Naftopidil dihydrochloride

Chemical Property:

• Appearance/Colour: white solid
• Melting Point: 212-213°
• Refractive Index: 1.619
• Boiling Point: 602.8 °C at 760 mmHg
• Flash Point: 318.3 °C
• PSA: 45.17000
• Density: 1.184g/cm³
• LogP: 5.01720
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: methanol: >10?mg/mL
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 464.1633482
• Heavy Atom Count: 31
• Complexity: 483

Purity/Quality:

98%Min ^*data from raw suppliers

NaftopidilDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O.Cl.Cl
• Uses: Antihypertensive;Alpha1 agonist

Technology Process of Naftopidil dihydrochloride

There total 2 articles about Naftopidil dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-(1-naphthyloxy)-1,2-epoxypropane (2461-42-9) + 1-(2-Methoxyphenyl)piperazine (35386-24-4) → (2RS)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalene-1-yloxy)propan-2-ol monohydrochloride (1164469-60-6,57149-08-3)

Guidance literature:

In toluene;

Reference yield:

α-naphthol (90-15-3) → (2RS)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalene-1-yloxy)propan-2-ol monohydrochloride (1164469-60-6,57149-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium methylate / methanol

2: toluene

With sodium methylate; In methanol; toluene;

upstream raw materials:

α-naphthol

3-(1-naphthyloxy)-1,2-epoxypropane

1-(2-Methoxyphenyl)piperazine

Refernces