4-CHLORO-5-METHYLISATIN

Base Information

• Chemical Name: 4-CHLORO-5-METHYLISATIN
• CAS No.: 53003-18-2
• Molecular Formula: C9H6ClNO2
• Molecular Weight: 195.6
• Mol file: 53003-18-2.mol

Synonyms:4-CHLORO-5-METHYLISATIN

Chemical Property of 4-CHLORO-5-METHYLISATIN

Chemical Property:

Purity/Quality:

99%min ^*data from raw suppliers

4-Chloro-5-methylisatin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-5-METHYLISATIN

There total 5 articles about 4-CHLORO-5-METHYLISATIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3-chloro-4-methyl-phenyl)-2-hydroxyimino-acetamide (155184-79-5) → 4-chloro-5-methyl-1H-indole-2,3-dione (53003-18-2) + 6-chloro-5-methylisatin (96187-75-6)

Guidance literature:

With sulfuric acid; at 60 - 80 ℃;

DOI:10.1016/S0968-0896(02)00018-4

Reference yield:

3-chloro-p-toluidine (95-74-9,827571-80-2) → 4-chloro-5-methyl-1H-indole-2,3-dione (53003-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; hydroxylamine sulfate

2: concentrated sulfuric acid / 90 - 95 °C / Verduennen der Reaktions-Loesung mit Wasser

With sulfuric acid; hydroxylamine sulfate;

Reference yield:

3-chloro-4-methylaniline hydrochloride (7745-89-3) → 4-chloro-5-methyl-1H-indole-2,3-dione (53003-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂SO₄; H₂NOH*HCl / H₂O / 0.67 h / Heating

2: conc. H₂SO₄ / 60 - 80 °C

With sulfuric acid; hydroxylamine hydrochloride; sodium sulfate; In water;

DOI:10.1016/S0968-0896(02)00018-4

upstream raw materials:

N-(3-chloro-4-methyl-phenyl)-2-hydroxyimino-acetamide

3-chloro-4-methylaniline hydrochloride

3-chloro-p-toluidine

Downstream raw materials:

2-amino-5-methyl-6-chlorobenzoic acid

2-chloro-3-methylbenzoic acid

2-(N-tert-butyloxycarbonyl)amino-5-methyl-6-chlorobenzoic acid

methyl 2-(N-tert-butyloxycarbonyl)amino-5-methyl-6-chlorobenzoate

Refernces

• 1、 Forsch, Ronald A.,Wright, Joel E.,Rosowsky, Andre. "Synthesis and in vitro antitumor activity of thiophene analogues of 5-chloro-5,8-dideazafolic acid and 2-methyl-2-desamino-5-chloro-5,8-dideazafolic acid". . p. 2067 - 2076. Retrieved 2007/10/03.