Diphenyl(2-methoxyphenyl)phosphine

Base Information

• Chemical Name: Diphenyl(2-methoxyphenyl)phosphine
• CAS No.: 53111-20-9
• Molecular Formula: C19H17OP
• Molecular Weight: 292.317
• Hs Code.: 2909309090
• European Community (EC) Number: 625-558-8
• DSSTox Substance ID: DTXSID60345287
• Nikkaji Number: J1.066.564G
• Wikipedia: 2-(Diphenylphosphino)anisole
• Wikidata: Q72517578
• Mol file: 53111-20-9.mol

Synonyms:(2-methoxyphenyl)diphenylphosphine;53111-20-9;Diphenyl(2-methoxyphenyl)phosphine;(2-methoxyphenyl)-diphenylphosphane;(2-Methoxyphenyl)diphenylphosphane;Diphenyl(O-anisyl)phosphine;2-Methoxyphenyldiphenylphosphine;(O-Methoxyphenyl)diphenylphosphine;Diphenyl(o-methoxyphenyl)phosphine;o-Anisyldiphenylphosphine;SCHEMBL56425;Diphenyl-2-methoxyphenylphosphine;DTXSID60345287;(2-methoxyphenyl)-diphenylphosphine;(2-Methoxy-phenyl)diphenyl-phosphine;(2-methoxyphenyl)-diphenyl-phosphane;MFCD00008361;AKOS024386549;Phosphine, (2-methoxyphenyl)diphenyl-;CS-W013987;SC11174;Diphenyl(2-methoxyphenyl)phosphine, 98%;AS-62050;FT-0640131;D97454;A829403;J-500837

Chemical Property of Diphenyl(2-methoxyphenyl)phosphine

Chemical Property:

• Vapor Pressure: 4.47E-06mmHg at 25°C
• Melting Point: 124-126 °C(lit.)
• Refractive Index: ">
• Boiling Point: 394.5°Cat760mmHg
• Flash Point: 237.8°C
• PSA: 22.82000
• Density: g/cm³
• LogP: 3.45340
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 292.101702159
• Heavy Atom Count: 21
• Complexity: 276

Purity/Quality:

98%,99%, ^*data from raw suppliers

Diphenyl(2-methoxyphenyl)phosphine 98% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC=C1P(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of Diphenyl(2-methoxyphenyl)phosphine

There total 13 articles about Diphenyl(2-methoxyphenyl)phosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(2-methoxy-phenyl)-diphenyl-phosphane; compound with borane → (2-methoxyphenyl)diphenylphosphine (53111-20-9)

Guidance literature:

With methanol; 4 A molecular sieve; In tetrahydrofuran; at 68 ℃; for 70h;

DOI:10.1246/bcsj.77.1931

Reference yield: 91.0%

4-iodoanisol (529-28-2) + diphenylphosphane (829-85-6) → (2-methoxyphenyl)diphenylphosphine (53111-20-9)

Guidance literature:

diphenylphosphane; With copper(l) iodide; N,N`-dimethylethylenediamine; In toluene;

4-iodoanisol; With caesium carbonate; In toluene; at 110 ℃; for 20h;

DOI:10.1021/ol0346640

Reference yield: 90.0%

2-bromoanisole (578-57-4) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → (2-methoxyphenyl)diphenylphosphine (53111-20-9)

Guidance literature:

2-bromoanisole; With iodine; magnesium; ethylene dibromide; In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;

chloro-diphenylphosphine; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1002/aoc.3092

upstream raw materials:

methoxybenzene

chloro-diphenylphosphine

2-bromoanisole

2-methoxyphenylmagnesium bromide

Downstream raw materials:

ethyl-(2-methoxy-phenyl)-diphenyl-phosphonium; iodide

o-Methoxyphenyl-diphenyl-methyl-phosphoniumiodid

Rh₂(CF₃CO₂)4(P(C₆H₅)2(C₆H₄OCH₃))2

Rh₂Cl₂(CH₃CO₂)2(P(C₆H₅)2(C₆H₄OCH₃))2

Refernces

• 1、 -. "Novel neutral monodentate chelated manganese complex as well as preparation method and application thereof". Paragraph 0048-0052. . Retrieved 2020/10/20.
• 2、 Xu, Zhaotao,Wang, Pingping,Chen, Qiurong,Cai, Mingzhong. "A practical synthesis of unsymmetrical triarylphosphines by heterogeneous palladium(0)-catalyzed cross-coupling of aryl iodides with diphenylphosphine". . p. 50 - 58. Retrieved 2018/04/23.