2-Furancarboxylic acid, 2,5-dihydro-, methyl ester, (+)- (9CI)

Base Information

• Chemical Name: 2-Furancarboxylic acid, 2,5-dihydro-, methyl ester, (+)- (9CI)
• CAS No.: 53299-44-8
• Molecular Formula: C₆H₈O₃
• Molecular Weight: 128.128
• Mol file: 53299-44-8.mol

Synonyms:

Chemical Property of 2-Furancarboxylic acid, 2,5-dihydro-, methyl ester, (+)- (9CI)

Chemical Property:

• Boiling Point: 157.7±40.0 °C(Predicted)
• PSA: 35.53000
• Density: 1.157±0.06 g/cm3(Predicted)
• LogP: 0.11440

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Furancarboxylic acid, 2,5-dihydro-, methyl ester, (+)- (9CI)

There total 3 articles about 2-Furancarboxylic acid, 2,5-dihydro-, methyl ester, (+)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2,5-dihydrofuran-2-carboxylic acid (22694-55-9) + methyl iodide (74-88-4) → methyl 2,5-dihydro-2-furancarboxylate (96014-51-6,57259-68-4,53299-44-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetone; at 20 ℃; for 4h;

DOI:10.1021/acs.orglett.1c00353

Reference yield:

2-furanoic acid (88-14-2) + methyl iodide (74-88-4) → methyl 2,5-dihydro-2-furancarboxylate (96014-51-6,57259-68-4,53299-44-8)

Guidance literature:

With ammonia; lithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; Multistep reaction; 1.) C₂H₅OH; 2.) CH₃CN;

DOI:10.1016/S0040-4039(01)81580-X

Reference yield:

→ methyl 2,5-dihydro-2-furancarboxylate (96014-51-6,57259-68-4,53299-44-8)

Guidance literature:

2-Furancarbonsaeure, Red.;

DOI:10.1039/c39740000181

upstream raw materials:

2-furanoic acid

methyl iodide

2,5-dihydrofuran-2-carboxylic acid

Downstream raw materials:

3-Iodo-4-(4-methoxy-benzyloxycarbonylamino)-tetrahydro-furan-2-carboxylic acid methyl ester

4-Iodo-3-(4-methoxy-benzyloxycarbonylamino)-tetrahydro-furan-2-carboxylic acid methyl ester

2-Methyl-2,5-dihydro-furan-2-carboxylic acid methyl ester

4-Amino-4,5-dihydro-furan-2-carboxylic acid

Refernces

• 1、 Burkhart,Holbert,Metcalf. "Enantiospecific synthesis of (S)-4-amino-4,5-dihydro-2-furancarboxylic acid, a new suicide inhibitor of GABA-transaminase". . p. 5267 - 5270. Retrieved 2007/10/02.