6-Hydroxy Nicotinoyl Chloirde

Base Information

• Chemical Name: 6-Hydroxy Nicotinoyl Chloirde
• CAS No.: 57659-03-7
• Molecular Formula: C6H4ClNO2
• Molecular Weight: 157.556
• Mol file: 57659-03-7.mol

Synonyms:6-Hydroxy Nicotinoyl Chloirde

Chemical Property of 6-Hydroxy Nicotinoyl Chloirde

Chemical Property:

• PSA: 49.93000
• LogP: 0.75390

Purity/Quality:

98% ^*data from raw suppliers

3-PYRIDINECARBONYL CGLORIDE,1,6-DIHYDRO-6-OXO- 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Hydroxy Nicotinoyl Chloirde

There total 3 articles about 6-Hydroxy Nicotinoyl Chloirde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

6-hydroxy-3-pyridinecarboxylic acid (5006-66-6) → 2-hydroxy-5-pyridinecarboxylic acid chloride (57659-03-7)

Guidance literature:

6-hydroxy-3-pyridinecarboxylic acid; With pyridine; In acetonitrile; at 80 ℃; for 0.5h;

With thionyl chloride; In acetonitrile; at 80 ℃; for 1.5h;

Reference yield: 68.0%

4-hydroxynicotinic acid (609-70-1) → 6-oxo-1,6-dihydropyridine-3-carbonyl chloride (57659-03-7)

Guidance literature:

With pyridine; thionyl chloride; In acetonitrile; at 80 ℃; for 0.5h;

Reference yield:

6-hydroxynicotinic acid (5006-66-6) → 6-oxo-1,6-dihydropyridine-3-carbonyl chloride (57659-03-7)

Guidance literature:

With thionyl chloride; for 1h; Heating;

upstream raw materials:

6-hydroxynicotinic acid

4-hydroxynicotinic acid

6-hydroxy-3-pyridinecarboxylic acid

Downstream raw materials:

N-(3-{[2-(4-amino-furazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-6-{[2-(4-morpholinyl)ethyl]oxy}-3-pyridinecarboxamide

N-(4-fluorophenyl)-6-hydroxynicotinamide

N-(2-hydroxy-1-(4-(trifluoromethoxy)phenyl)ethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide

N-[3-(4-fluorophenyl)-3-(4-methanesulfonylphenyl)propyl]-6-hydroxy-nicotinamide

Refernces

• 1、 Eldrup, Anne B.,Soleymanzadeh, Fariba,Taylor, Steven J.,Muegge, Ingo,Farrow, Neil A.,Joseph, David,McKellop, Keith,Man, Chuk C.,Kukulka, Alison,De Lombaert, Stéphane. "Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase". experimental part. p. 5880 - 5895. Retrieved 2010/03/24.
• 2、 Kinoyama, Isao,Taniguchi, Nobuaki,Toyoshima, Akira,Nozawa, Eisuke,Kamikubo, Takashi,Imamura, Masakazu,Matsuhisa, Akira,Samizu, Kiyohiro,Kawanimani, Eiji,Niimi, Tatsuya,Hamada, Noritaka,Koutoku, Hiroshi,Furutani, Takashi,Kudoh, Masafumi,Okada, Minoru,Ohta, Mitsuaki,Tsukamoto, Shin-Ichi. "(+)-(2R,5S)-4-[4-cyano-3-(trifluoromethyl)phenyl]-2,5-dimethyl-N-[6- (trifluoromethyl)pyridin-3-yl]piperazine-1-carboxamide (YM580) as an orally potent and peripherally selective nonsteroidal androgen receptor antagonist". . p. 716 - 726. Retrieved 2007/10/03.