2,5-Dimethyl-3-piperazin-1-ylpyrazine

Base Information

• Chemical Name: 2,5-Dimethyl-3-piperazin-1-ylpyrazine
• CAS No.: 59215-42-8
• Molecular Formula: C₁₀H₁₆N₄
• Molecular Weight: 192.264
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID30396761
• Wikidata: Q82197649
• ChEMBL ID: CHEMBL3302928
• Mol file: 59215-42-8.mol

Synonyms:59215-42-8;2,5-dimethyl-3-piperazin-1-ylpyrazine;2,5-dimethyl-3-(piperazin-1-yl)pyrazine;Verkadebase;SCHEMBL1737167;CHEMBL3302928;DTXSID30396761;WFPZOAOJEXDUGP-UHFFFAOYSA-N;MFCD05182224;AKOS000123233;BS-38301;CS-0454077;FT-0647203;2,5-Dimethyl-3-piperazin-1-ylpyrazine, AldrichCPR;3',6'-dimethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl

Chemical Property of 2,5-Dimethyl-3-piperazin-1-ylpyrazine

Chemical Property:

• PSA: 41.05000
• LogP: 0.89680
• Storage Temp.: 2-8°C
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 192.137496527
• Heavy Atom Count: 14
• Complexity: 179

Purity/Quality:

98%min ^*data from raw suppliers

2,5-dimethyl-3-piperazin-1-ylpyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(C(=N1)N2CCNCC2)C

Technology Process of 2,5-Dimethyl-3-piperazin-1-ylpyrazine

There total 3 articles about 2,5-Dimethyl-3-piperazin-1-ylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

piperazine (110-85-0) + 2,5-dimethyl-3-chloropyrazine (95-89-6) → 4-(3,6-dimethylpyrazinyl)piperazine (59215-42-8)

Guidance literature:

With triethylamine; at 150 ℃;

DOI:10.1002/ardp.200600106

Reference yield: 45.0%

2,5-dimethyl-3-[4-(phenylmethyl)piperazin-1-yl]pyrazine (111669-48-8) → 4-(3,6-dimethylpyrazinyl)piperazine (59215-42-8)

Guidance literature:

With ammonium formate; palladium 10% on activated carbon; In methanol; Heating / reflux;

Reference yield:

→ 4-(3,6-dimethylpyrazinyl)piperazine (59215-42-8)

Guidance literature:

3,6-Dimethyl-2-chloropyrazin, wfr. Piperazin, 140grad;

DOI:10.1021/jm00273a600

upstream raw materials:

piperazine

2,5-dimethyl-3-chloropyrazine

2,5-dimethyl-3-[4-(phenylmethyl)piperazin-1-yl]pyrazine

Refernces

• 1、 -. "ANTIPARASITIC TERPENE ALKALOIDS". Page 155. . Retrieved 2008/06/13.