DIMETHYL 2-AMINOMALONATE, TECH

Base Information

• Chemical Name: DIMETHYL 2-AMINOMALONATE, TECH
• CAS No.: 53704-09-9
• Molecular Formula: C5H9NO4
• Molecular Weight: 147.131
• Hs Code.: 2922499990
• Mol file: 53704-09-9.mol

Synonyms:Dimethyl 2-aminopropane-1,3-dioate;

Chemical Property of DIMETHYL 2-AMINOMALONATE, TECH

Chemical Property:

• Boiling Point: 155.7 °C at 760 mmHg
• PKA: 15.30±0.59(Predicted)
• Flash Point: 33.2 °C
• PSA: 78.62000
• Density: 1.205 g/cm³
• LogP: -0.64000
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Dimethyl 2-aminomalonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIMETHYL 2-AMINOMALONATE, TECH

There total 4 articles about DIMETHYL 2-AMINOMALONATE, TECH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

dimethyl 2-(hydroxyimino)malonate (42937-74-6) → dimethyl 2-aminomalonate (53704-09-9)

Guidance literature:

With palladium on carbon; hydrogen; In methanol; at 20 ℃;

DOI:10.1016/j.tet.2011.05.112

Reference yield: 55.2%

dimethyl formamidomalonate (27160-23-2) → dimethyl 2-aminomalonate (53704-09-9)

Guidance literature:

With hydrogenchloride; In ethanol; Heating;

Reference yield:

malonic acid dimethyl ester (108-59-8) → dimethyl 2-aminomalonate (53704-09-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaNO₂; aq. acetic acid / 0 - 23 °C

2: 58.3 g / H₂ / Pd/C / ethanol / 12 h / 23 °C / 72400.7 Torr

With hydrogen; acetic acid; sodium nitrite; palladium on activated charcoal; In ethanol;

DOI:10.1021/ja035303i

upstream raw materials:

dimethyl 2-(hydroxyimino)malonate

dimethyl formamidomalonate

malonic acid dimethyl ester

Downstream raw materials:

[(N-benzyloxycarbonyl-glycyl)-amino]-malonic acid dimethyl ester

dimethyl diazomalonate

dimethyl N-benzyloxycarbonyl-L-prolylaminomalonate

2-{[1-Phenyl-meth-(E)-ylidene]-amino}-malonic acid dimethyl ester

Refernces

• 1、 Yamada, Ken,Kurokawa, Toshiki,Tokuyama, Hidetoshi,Fukuyama, Tohru. "Total synthesis of the duocarmycins". . p. 6630 - 6631. Retrieved 2007/10/03.
• 2、 Hosmane, Ramachandra S.,Lim, Benjamin B.. "A GENERAL METHOD FOR THE SYNTHESIS OF 1-SUBSTITUTED (OR UNSUBSTITUTED)-4-CARBOMETHOXY-2-IMIDAZOLIN-5-ONES". . p. 1915 - 1918. Retrieved 2007/10/02.