2-Amino-5-chlorobenzenesulfonamide

Base Information

• Chemical Name: 2-Amino-5-chlorobenzenesulfonamide
• CAS No.: 5790-69-2
• Molecular Formula: C6H7ClN2O2S
• Molecular Weight: 206.653
• Hs Code.: 2935009090
• European Community (EC) Number: 637-334-7
• ChEMBL ID: CHEMBL448692
• DSSTox Substance ID: DTXSID60485475
• Nikkaji Number: J715.926I
• Wikidata: Q69756788
• Mol file: 5790-69-2.mol

Synonyms:2-amino-5-chlorobenzenesulfonamide;5790-69-2;2-amino-5-chlorobenzene-1-sulfonamide;2-Amino-5-chlorobenzenesulphonamide;2-amino-5-chloro-benzenesulfonamide;CHEMBL448692;SCHEMBL2131504;DTXSID60485475;RBCLOSOKWLMKMB-UHFFFAOYSA-N;MFCD08741416;AKOS009463147;PS-4110;SB78107;FT-0744453;C16020;EN300-272165;A869562;ethyl?5,5-dimethyl-1-tosylpyrrolidine-2-carboxylate;J-507931

Chemical Property of 2-Amino-5-chlorobenzenesulfonamide

Chemical Property:

• Vapor Pressure: 1.05E-07mmHg at 25°C
• Melting Point: 148-150°C
• Refractive Index: 1.587
• Boiling Point: 433.1 °C at 760 mmHg
• PKA: 10.02±0.60(Predicted)
• Flash Point: 215.7 °C
• PSA: 94.56000
• Density: 1.558 g/cm³
• LogP: 2.93190
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 205.9916763
• Heavy Atom Count: 12
• Complexity: 249

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-5-chlorobenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)S(=O)(=O)N)N

Technology Process of 2-Amino-5-chlorobenzenesulfonamide

There total 10 articles about 2-Amino-5-chlorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

7-chloro-2,3-dihydro-3-oxo-4H-1,2,4-benzothiadiazine (5800-59-9) → 2-amino-5-chlorobenzenesulfonamide (5790-69-2)

Guidance literature:

7-chloro-2,3-dihydro-3-oxo-4H-1,2,4-benzothiadiazine; With sulfuric acid; water; at 130 - 140 ℃; for 3h;

With sodium hydroxide; In water;

With hydrogenchloride; In water; pH=3;

DOI:10.1016/j.bmc.2009.10.024

Reference yield: 95.0%

2-AMINOBENZENESULFONAMIDE (3306-62-5) → 2-amino-5-chlorobenzenesulfonamide (5790-69-2)

Guidance literature:

With N-chloro-succinimide; In chloroform; for 3h; Solvent; Reflux;

Reference yield:

5-chloro-2-nitrobenzenesulfonamide (68379-05-5) → 2-amino-5-chlorobenzenesulfonamide (5790-69-2)

Guidance literature:

With iron; ammonium chloride; In methanol; for 7h; Reflux;

upstream raw materials:

4-Chlor-2-acetylsulfamoyl-acetanilid

7-chloro-2,3-dihydro-3-oxo-4H-1,2,4-benzothiadiazine

4-chloro-aniline

C₇H₆Cl₂N₂O₃S

Downstream raw materials:

ethyl 2-[2-(aminosulfonyl)-4-chloroanilino]-2-oxoacetate

7-chloro-3-(4-methylphenyl)-4H-1,2,4-benzothiadiazine-1,1-dioxide

7-chloro-3-(4-chlorophenyl)-4H-1,2,4-benzothiadiazine-1,1-dioxide

7-chloro-3-(3-fluorophenyl)-4H-1,2,4-benzothiadiazine-1,1-dioxide

Refernces

• 1、 -. "Synthetic method of diazoxide". Paragraph 0034; 0035. . Retrieved 2017/08/29.
• 2、 Khelili, Smail,Kihal, Nadjib,Yekhlef, Mohamed,De Tullio, Pascal,Lebrun, Philippe,Pirotte, Bernard. "Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1- benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells". scheme or table. p. 873 - 878. Retrieved 2012/09/10.