4-Chloro-3-fluoro-2-Methylpyridine

Base Information

• Chemical Name: 4-Chloro-3-fluoro-2-Methylpyridine
• CAS No.: 1195-25-1
• Molecular Formula: C4H3 Cl3 N2 O
• Molecular Weight: 201.44
• Hs Code.: 2934999090
• Mol file: 1195-25-1.mol

Synonyms:3-Methyl-5-(trichloromethyl)-1,2,4-oxadiazole

Chemical Property of 4-Chloro-3-fluoro-2-Methylpyridine

Chemical Property:

• Vapor Pressure: 0.391mmHg at 25°C
• Boiling Point: 203.7°C at 760 mmHg
• Flash Point: 77°C
• PSA: 38.92000
• Density: 1.595g/cm³
• LogP: 2.20470

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Methyl-5-(trichloromethyl)-1,2,4-oxadiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-3-fluoro-2-Methylpyridine

There total 4 articles about 4-Chloro-3-fluoro-2-Methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

Nitroethane (79-24-3) + phenyl isocyanate (103-71-9) + trichloroacetonitrile (545-06-2) → 3-methyl-5-trichloromethyl-1,2,4-oxadiazole (1195-25-1)

Guidance literature:

With triethylamine; In toluene; for 24h; ultrasound;

DOI:10.1016/0040-4039(95)00755-2

Reference yield: 52.0%

acetamide oxime (118493-85-9,117771-39-8,1141922-26-0,1429624-21-4) + trichloroacetic acid anhydride (4124-31-6) → 3-methyl-5-trichloromethyl-1,2,4-oxadiazole (1195-25-1)

Guidance literature:

acetamide oxime; trichloroacetic acid anhydride; With mercury; at 120 - 130 ℃; for 3h;

With sodium hydrogencarbonate; In water;

Reference yield:

→ (S,S)-2-(tert-Butyloxycarbonyl)-5-(3-methyl-1,2,3-oxadiazol-5-yl)-2,5-diazabicyclo[2.2.1]heptane + 3-methyl-5-trichloromethyl-1,2,4-oxadiazole (1195-25-1)

Guidance literature:

upstream raw materials:

acetamide oxime

trichloroacetic acid anhydride

Nitroethane

phenyl isocyanate

Downstream raw materials:

5-methyl-[1,2,4]oxadiazole-3-carboxylic acid

5-dichloromethyl-3-methyl-1,2,4-oxadiazole

di(p-tolyl) disulfide

2-{3,5-dimethyl-4-[2-(3-methyl[1,2,4]oxadiazol-5-ylamino)ethoxy]phenyl}-5,7-dimethoxy-3H-quinazolin-4-one

Refernces

• 1、 -. "NOVEL ANTI-INFLAMMATORY AGENTS". Page/Page column 105-106. . Retrieved 2010/11/05.
• 2、 Bolton, Richard E.,Coote, Steven J.,Finch, Harry,Lowdon, Andrew,Pegg, Neil,Vinader, M. Victoria. "3-Substituted-1,2,4-Oxadiazolin-5-one; A Useful Amidine Precursor and Protecting Group". . p. 4471 - 4474. Retrieved 2007/10/02.