2-METHOXY-N4-PHENYL-1,4-PHENYLENEDIAMINE

Base Information

• Chemical Name: 2-METHOXY-N4-PHENYL-1,4-PHENYLENEDIAMINE
• CAS No.: 5840-10-8
• Molecular Formula: C13H14N2O
• Molecular Weight: 214.267
• Mol file: 5840-10-8.mol

Synonyms:(4-Amino-3-methoxyphenyl)phenylamine;

Chemical Property of 2-METHOXY-N4-PHENYL-1,4-PHENYLENEDIAMINE

Chemical Property:

• Vapor Pressure: 1.1E-05mmHg at 25°C
• Melting Point: 86-88 °C(lit.)
• Refractive Index: 1.653
• Boiling Point: 370.6 °C at 760 mmHg
• Flash Point: 177.9 °C
• Density: 1.178 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

2-Methoxy-N4-phenyl-1,4-phenylenediamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Methoxy-N4-phenyl-1,4-phenylenediamine is a stain/dye. Dyes and metabolites.

Technology Process of 2-METHOXY-N4-PHENYL-1,4-PHENYLENEDIAMINE

There total 14 articles about 2-METHOXY-N4-PHENYL-1,4-PHENYLENEDIAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-methoxy-4-nitro-N-phenylaniline → 1-amino-2-methoxy-4-(N-phenylamino)benzene (5840-10-8)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 24h; under 760.051 Torr;

Reference yield:

5-bromo-2-nitrophenol (27684-84-0) → 1-amino-2-methoxy-4-(N-phenylamino)benzene (5840-10-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 20 h / 90 °C

2: XPhos; palladium diacetate; caesium carbonate / toluene; tert-butyl alcohol / 1 h / 150 °C / Microwave irradiation

3: palladium on activated charcoal; hydrogen / methanol / 24 h / 20 °C / 760.05 Torr

With palladium on activated charcoal; hydrogen; palladium diacetate; potassium carbonate; caesium carbonate; XPhos; In methanol; acetone; toluene; tert-butyl alcohol;

Reference yield:

4-bromo-2-methoxy-1-nitro-benzene (103966-66-1) → 1-amino-2-methoxy-4-(N-phenylamino)benzene (5840-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1: XPhos; palladium diacetate; caesium carbonate / toluene; tert-butyl alcohol / 1 h / 150 °C / Microwave irradiation

2: palladium on activated charcoal; hydrogen / methanol / 24 h / 20 °C / 760.05 Torr

With palladium on activated charcoal; hydrogen; palladium diacetate; caesium carbonate; XPhos; In methanol; toluene; tert-butyl alcohol;

upstream raw materials:

(3-methoxy-4-nitroso-phenyl)-phenyl-amine

N-(3-methoxy-4-nitro-phenyl)-N-phenyl-formamide

2-nitrosoanisole

Nitrosobenzene

Downstream raw materials:

GSK0660

(2RS,3R)-3-amino-N-(4-anilino-2-methoxyphenyl)-4-cyclohexyl-2-hydroxybutanamide hydrochloride

Refernces

• 1、 Mao, Jian-Hui,Wang, Yong-Bin,Yang, Limin,Xiang, Shao-Hua,Wu, Quan-Hao,Cui, Yuan,Lu, Qian,Lv, Jie,Li, Shaoyu,Tan, Bin. "Organocatalyst-controlled site-selective arene C–H functionalization". . p. 982 - 991. Retrieved 2021/08/12.
• 2、 -. "Light-sensitive polycondensation product containing diazonium and dialdehyde groups, and light-sensitive recording material prepared therewith". . . Retrieved 2008/06/13.