N-(pyridin-2-ylmethyl)acetamide

Base Information

• Chemical Name: N-(pyridin-2-ylmethyl)acetamide
• CAS No.: 58481-18-8
• Molecular Formula: C8H10N2O
• Molecular Weight: 150.18
• ChEMBL ID: CHEMBL3244510
• DSSTox Substance ID: DTXSID20408160
• Nikkaji Number: J1.781.529F
• Wikidata: Q82213539
• Mol file: 58481-18-8.mol

Synonyms:58481-18-8;N-(pyridin-2-ylmethyl)acetamide;2-ACETYLAMINOMETHYL PYRIDINE;N-[(pyridin-2-yl)methyl]acetamide;2-acetylaminomethylpyridine;n-picolylacetamide;N-2-Pyridylmethylacetamide;Oprea1_203462;SCHEMBL48805;CHEMBL3244510;DTXSID20408160;ACOHAEBNFWGQCL-UHFFFAOYSA-N;MFCD01195297;AKOS003860322;NS-01153;8UA

Chemical Property of N-(pyridin-2-ylmethyl)acetamide

Chemical Property:

• PSA: 41.99000
• LogP: 1.10860
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 150.079312947
• Heavy Atom Count: 11
• Complexity: 136

Purity/Quality:

99%min ^*data from raw suppliers

N-(pyridin-2-ylmethyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NCC1=CC=CC=N1

Technology Process of N-(pyridin-2-ylmethyl)acetamide

There total 8 articles about N-(pyridin-2-ylmethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(Aminomethyl)pyridine (3731-51-9) + tetraacetoxysilane (562-90-3) → N-(pyridin-2-ylmethyl)acetamide (58481-18-8)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1002/ejoc.201901660

Reference yield: 93.0%

acetamide (60-35-5) + 2-(Aminomethyl)pyridine (3731-51-9) → N-(pyridin-2-ylmethyl)acetamide (58481-18-8)

Guidance literature:

With C₂₈H₂₆ClN₃ORuS; In 1,4-dioxane; at 100 ℃; for 8h; Sealed tube; Inert atmosphere;

DOI:10.1016/j.jorganchem.2020.121555

Reference yield: 79.0%

acetylaminoacetonitrile (4814-80-6) + acetylene (74-86-2,25067-58-7) → N-(pyridin-2-ylmethyl)acetamide (58481-18-8)

Guidance literature:

(η5-cyclopentadienyl)-η4-cycloocta-1,5-dienecobalt(I); In toluene; at 25 ℃; Irradiation;

DOI:10.1021/jo011032n

upstream raw materials:

2-(Aminomethyl)pyridine

acetic anhydride

acetylaminoacetonitrile

acetylene

Downstream raw materials:

2-(Aminomethyl)pyridine

3-methylimidazo<1,5-a>pyridine

N-((1-oxy-pyridin-2-yl)methyl)acetamide

acetonitrile(N-(2-pyridylmethyl)acetamide)(triphenylphosphine)copper(I) hexafluorophosphate

Refernces

• 1、 Omer, Humair M.,Liu, Peng,Brummond, Kay M.. "Metal-Free C-C Coupling of an Allenyl Sulfone with Picolyl Amides to Access Vinyl Sulfones via Pyridine-Initiated in Situ Generation of Sulfinate Anion". . p. 7959 - 7975. Retrieved 2020/07/15.
• 2、 Vijayapritha, Subbarayan,Viswanathamurthi, Periasamy. "New half-sandwich (η6-p-cymene)ruthenium(II) complexes with benzothiazole hydrazone Schiff base ligand: Synthesis, structural characterization and catalysis in transamidation of carboxamide with primary amines". supporting information. . Retrieved 2020/10/18.