1H-1,2,4-TRIAZOLE-3-METHANAMINE

Base Information

• Chemical Name: 1H-1,2,4-TRIAZOLE-3-METHANAMINE
• CAS No.: 58502-29-7
• Molecular Formula: C3H6N4
• Molecular Weight: 98.1074
• Hs Code.: 2933998090
• Mol file: 58502-29-7.mol

Synonyms:2H-[1,2,4]TRIAZOL-3-YL-METHYLAMINE;1H-1,2,4-TRIAZOLE-3-METHANAMINE;1H-1,2,4-TRIAZOLE-3-METHANEAMINE;(1H-1,2,4-TRIAZOL-3-YL)METHANAMINE HYDROCHLORIDE;C-(2H-[1,2,4]TRIAZOL-3-YL)-METHYLAMINE;(1H-1,2,4-TRIAZOL-5-YL)METHANAMINE

Chemical Property of 1H-1,2,4-TRIAZOLE-3-METHANAMINE

Chemical Property:

• Vapor Pressure: 0.000503mmHg at 25°C
• Melting Point: 225 °C
• Refractive Index: 1.598
• Boiling Point: 313.2°C at 760 mmHg
• PKA: 7.18±0.20(Predicted)
• Flash Point: 169°C
• PSA: 67.59000
• Density: 1.322g/cm³
• LogP: -0.03630
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%min ^*data from raw suppliers

3-(Aminomethyl)-1,2,4-triazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (1H-1,2,4-Triazol-5-ylmethyl)amine is used as a reactant in the preparation of peptidomimetics as granzyme B inhibitors for the treatment of autoimmune, inflammatory and related diseases.

Technology Process of 1H-1,2,4-TRIAZOLE-3-METHANAMINE

There total 2 articles about 1H-1,2,4-TRIAZOLE-3-METHANAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H22N4O3 → C-(1H-[1,2,4]triazol-3-yl)-methylamine (58502-29-7)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 30 ℃; for 0.5h; Inert atmosphere;

Reference yield:

→ C-(1H-[1,2,4]triazol-3-yl)-methylamine (58502-29-7)

Guidance literature:

aus dem Salz 7 unf H2SO4;

DOI:10.1021/jo00873a001

Reference yield: 82.0%

5-allyl-2,3,5-trichloro-4,4-dimethoxy-2-cyclopentenone (126517-92-8) + (1H-1,2,4-triazol-5-yl)methanamine (58502-29-7) → 5-Allyl-2,5-dichloro-4,4-dimethoxy-3-[(2H-[1,2,4]triazol-3-ylmethyl)-amino]-cyclopent-2-enone (144970-11-6)

Guidance literature:

In methanol; at 20 ℃; for 4h;

DOI:10.1007/BF00773167

Downstream raw materials:

5-Allyl-2,5-dichloro-4,4-dimethoxy-3-[(2H-[1,2,4]triazol-3-ylmethyl)-amino]-cyclopent-2-enone

3-[{1-[Bis(4-chlorophenyl)methyl]azetidin-3-yl}(methylsulphonyl)amino]-N-(1H-1,2,4-triazol-3-ylmethyl)benzamide

Refernces