Ethanol, 2-[(2-fluoro-4-nitrophenyl)amino]- (9CI)

Base Information

• Chemical Name: Ethanol, 2-[(2-fluoro-4-nitrophenyl)amino]- (9CI)
• CAS No.: 509151-97-7
• Molecular Formula: C8H9FN2O3
• Molecular Weight: 200.1670632
• Hs Code.: 2922199090
• Mol file: 509151-97-7.mol

Synonyms:Ethanol, 2-[(2-fluoro-4-nitrophenyl)amino]- (9CI)

Chemical Property of Ethanol, 2-[(2-fluoro-4-nitrophenyl)amino]- (9CI)

Chemical Property:

• Boiling Point: 381.2±37.0 °C(Predicted)
• PKA: 14.51±0.10(Predicted)
• PSA: 78.08000
• Density: 1.440±0.06 g/cm3(Predicted)
• LogP: 1.73430

Purity/Quality:

99% ^*data from raw suppliers

2-[(2-Fluoro-4-nitrophenyl)amino]ethan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-[(2-Fluoro-4-nitrophenyl)amino]ethan-1-ol is a chemical reagent used in the synthesis of oxazolidinone compounds as antibiotics and other anti-bacterial agents.

Technology Process of Ethanol, 2-[(2-fluoro-4-nitrophenyl)amino]- (9CI)

There total 4 articles about Ethanol, 2-[(2-fluoro-4-nitrophenyl)amino]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,4-difluoronitrobenzene (369-34-6) + ethanolamine (141-43-5) → 2-(2-fluoro-4-nitrophenylamino)ethanol (509151-97-7)

Guidance literature:

In acetonitrile; for 4h; Reflux;

Reference yield: 82.0%

2-(2-fluoro-4-nitro-phenoxy)-ethylamine; hydrochloride → 2-(2-fluoro-4-nitrophenylamino)ethanol (509151-97-7)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; at 60 ℃; for 4h;

DOI:10.1055/s-2002-35227

Reference yield:

3,4-difluoronitrobenzene (369-34-6) → 2-(2-fluoro-4-nitrophenylamino)ethanol (509151-97-7)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran / 20 °C

2: aq. HCl / Heating

3: 82 percent / aq. KOH / tetrahydrofuran; dimethylsulfoxide / 4 h / 60 °C

With hydrogenchloride; potassium hydroxide; sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; 3: Smiles rearrangement;

DOI:10.1055/s-2002-35227

upstream raw materials:

3,4-difluoronitrobenzene

N-[2-(2-fluoro-4-nitro-phenoxy)-ethyl]-acetamide

ethanolamine

Refernces

• 1、 -. "NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES". Page/Page column 105-106. . Retrieved 2012/12/13.
• 2、 -. "NOVEL OXAZOLIDINONE DERIVATIVES WITH CYCLIC AMIDOXIME OR CYCLIC AMIDRAZONE AND PHARMACEUTICAL COMPOSITIONS THEREOF". Page/Page column 27. . Retrieved 2010/04/27.