3-Chloro-2-morpholin-4-ylaniline

Base Information

• Chemical Name: 3-Chloro-2-morpholin-4-ylaniline
• CAS No.: 58785-07-2
• Molecular Formula: C10H13ClN2O
• Molecular Weight: 212.68
• Hs Code.: 2934999090
• European Community (EC) Number: 804-140-0
• DSSTox Substance ID: DTXSID80359220
• Wikidata: Q82140320
• ChEMBL ID: CHEMBL1702883
• Mol file: 58785-07-2.mol

Synonyms:58785-07-2;3-chloro-2-morpholin-4-ylaniline;3-Chloro-2-morpholinoaniline;3-Chloro-2-morpholin-4-yl-phenylamine;3-chloro-2-(morpholin-4-yl)aniline;(3-chloro-2-morpholin-4-ylphenyl)amine;3-chloro-2-(4-morpholinyl)aniline;3-chloro-2-morpholin-4-ylphenylamine;MLS000523569;SCHEMBL3727243;CHEMBL1702883;DTXSID80359220;HMS1684A18;HMS2354H22;MFCD03821863;STK141091;AKOS000103634;3-chloro-2-(4-morpholinyl)phenylamine;LS-02105;SMR000122642;3,5-BIS-TRIMETHYLSILANYL-BENZOICACID;BB 0245140;CS-0243570;FT-0677117;EN300-26586;A869363;3-chloro-2-morpholin-4-yl-phenylamine, AldrichCPR;Z57662465

Chemical Property of 3-Chloro-2-morpholin-4-ylaniline

Chemical Property:

• Vapor Pressure: 1.67E-05mmHg at 25°C
• Refractive Index: 1.6
• Boiling Point: 364.6°C at 760 mmHg
• Flash Point: 174.3°C
• PSA: 38.49000
• Density: 1.273g/cm³
• LogP: 2.40500
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 212.0716407
• Heavy Atom Count: 14
• Complexity: 185

Purity/Quality:

98%min ^*data from raw suppliers

3-Chloro-2-morpholin-4-ylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=C(C=CC=C2Cl)N

Technology Process of 3-Chloro-2-morpholin-4-ylaniline

There total 1 articles about 3-Chloro-2-morpholin-4-ylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

morpholine (110-91-8,99108-56-2) + 1,2-Dichloro-3-nitrobenzene (3209-22-1) → 3-chloro-2-(morpholin-4-yl)aniline (58785-07-2)

Guidance literature:

Multistep reaction; (i), (ii) (reduction);

Reference yield: 71.0%

3-chloro-2-(morpholin-4-yl)aniline (58785-07-2) + benzyl alcohol (100-51-6,185532-71-2) → 3-chloro-N-(1,2-diphenylethyl)-2-morpholinoaniline

Guidance literature:

With palladium diacetate; sodium 3-(diphenylphosphanyl)benzenesulfonate; In water; at 120 ℃; for 20h; chemoselective reaction; Sealed tube; Green chemistry;

DOI:10.1039/c7gc03780e

Reference yield: 50.7%

3-chloro-2-(morpholin-4-yl)aniline (58785-07-2) + 3-cyclopropyl-benzenesulfonyl chloride (958651-12-2) → C19H21ClN2O3S

Guidance literature:

With pyridine; at 100 ℃; for 16h;

upstream raw materials:

morpholine

1,2-Dichloro-3-nitrobenzene

Downstream raw materials:

(3-chloro-2-morpholin-4-yl-anilinomethylene)-malonic acid diethyl ester

1-[(2-chloro-4-fluorophenyl)methyl]-4-[3-chloro-2-(4-morpholinyl)phenyl]-2,3-piperazinedione