7-Hydroxy-4-phenyl-2-chromanone

Base Information

• Chemical Name: 7-Hydroxy-4-phenyl-2-chromanone
• CAS No.: 6275-80-5
• Molecular Formula: C15H12 O3
• Molecular Weight: 240.258
• NSC Number: 36162
• Nikkaji Number: J1.465.113F
• ChEMBL ID: CHEMBL1486811
• Mol file: 6275-80-5.mol

Synonyms:MLS000738116;NSC-36162;7-hydroxy-4-phenyl-2-chromanone;SMR000135196;NSC36162;Oprea1_084961;Oprea1_536021;CBDivE_007599;MLS000530219;CHEMBL1486811;SCHEMBL13194998;HMS2389A20;STK746666;AKOS000560181;AKOS016371030;WAY-300580;3,4-dihydro-7-hydroxy-4-phenylcoumarin;AB00075316-01;7-hydroxy-4-phenyl-3,4-dihydro-2H-chromen-2-one

Chemical Property of 7-Hydroxy-4-phenyl-2-chromanone

Chemical Property:

• Vapor Pressure: 9.05E-17mmHg at 25°C
• Boiling Point: 649.8°C at 760 mmHg
• Flash Point: 346.8°C
• Density: 1.33g/cm³
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 240.078644241
• Heavy Atom Count: 18
• Complexity: 309

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(C2=C(C=C(C=C2)O)OC1=O)C3=CC=CC=C3

Technology Process of 7-Hydroxy-4-phenyl-2-chromanone

There total 11 articles about 7-Hydroxy-4-phenyl-2-chromanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(E)-3-phenylacrylic acid (140-10-3) + recorcinol (108-46-3) → (±)-7-hydroxy-4-phenyl-3,4-dihydrocoumarin (6275-80-5)

Guidance literature:

With Montmorillonite KSF clay; zinc(II) chloride; for 0.333333h; Irradiation;

DOI:10.1039/a708103k

Reference yield: 75.0%

N-formamido-3-phenyl-2-propenamide (5962-06-1) + recorcinol (108-46-3) → (±)-7-hydroxy-4-phenyl-3,4-dihydrocoumarin (6275-80-5)

Guidance literature:

With PPA; at 130 ℃; for 5h;

Reference yield: 68.0%

methyl cinnamate (103-26-4,1754-62-7) + recorcinol (108-46-3) → (±)-7-hydroxy-4-phenyl-3,4-dihydrocoumarin (6275-80-5) + 5-hydroxy-4-phenyl-3,4-dihydro-2H-chromen-2-one

Guidance literature:

With iron(III) chloride; In chloroform; for 2h; Heating;

upstream raw materials:

O-methylresorcine

(E)-3-phenylacrylic acid

7-hydroxy-4-phenylcoumarin

recorcinol

Downstream raw materials:

7-(4-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)butoxy)-4-phenylchroman-2-one

7-(4-bromobutoxy)-4-phenylchroman-2-one

4-[3-(1-Methyl-3,3-diphenyl-propylamino)-1-phenyl-propyl]-benzene-1,3-diol

4-[3-(3,3-Diphenyl-propylamino)-1-phenyl-propyl]-benzene-1,3-diol

Refernces

• 1、 Naik, Mayuri M.,Kamat, Durga P.,Tilve, Santosh G.,Kamat, Vijayendra P.. "Molecular iodine catalyst promoted synthesis of chromans and 4-aryl-3,4-dihydrobenzopyran-2-ones via [3+3] cyclocoupling". . p. 5221 - 5233. Retrieved 2014/07/08.
• 2、 Majumder,Chatterjee,Mukhoti. "The reactions of phenols with α,β-unsaturated aromatic acids in presence of polyphosphoric acid: Synthetic and mechanistic studies". . p. 743 - 755. Retrieved 2007/10/03.