Adenosine-5''-O-(1-thiotriphosphoric acid), Sp-isomer

Base Information

• Chemical Name: Adenosine-5''-O-(1-thiotriphosphoric acid), Sp-isomer
• CAS No.: 58976-48-0
• Molecular Formula: C10H16N5O12P3S
• Molecular Weight: 523.251
• Mol file: 58976-48-0.mol

Synonyms:Adenosine-5''-O-(1-thiotriphosphoric acid), Sp-isomer

Chemical Property of Adenosine-5''-O-(1-thiotriphosphoric acid), Sp-isomer

Chemical Property:

• PSA: 323.58000
• LogP: -0.28080

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Adenosine-5''-O-(1-thiotriphosphoric acid), Sp-isomer

There total 3 articles about Adenosine-5''-O-(1-thiotriphosphoric acid), Sp-isomer which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

AMPS (19341-57-2) → (SP)-Adenosine-5'-O-(1-Thiotriphosphate) (58976-48-0)

Guidance literature:

With adenylate and pyruvate kinase in acrylamide; N-acrylsuccinimide-copolymer; phospho(enol)pyruvic acid mono potassium salt; ATP; magnesium chloride; diothiothreitol; In water; at 37 ℃; for 120h; Yield given;

DOI:10.1021/jo00178a028

Reference yield:

adenosine (58-61-7) → (SP)-Adenosine-5'-O-(1-Thiotriphosphate) (58976-48-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / Thiophosphorylchloride, 2,6-dimethylpyridine / various solvent(s) / 0.75 h / 5 °C

2: potassium phosphoenol pyruvate, dithiothreitol, ATP, MgCl₂*6H₂O; adenylate and pyruvate kinase in acrylamide/N-acrylsuccinimide-copolymer / H₂O / 120 h / 37 °C

With 2,6-dimethylpyridine; trichlorothiophosphine; adenylate and pyruvate kinase in acrylamide; N-acrylsuccinimide-copolymer; phospho(enol)pyruvic acid mono potassium salt; ATP; magnesium chloride; diothiothreitol; In water;

DOI:10.1021/jo00178a028

Reference yield:

AMPS (19341-57-2) → Adenosine 5'<(S)α-thio>triphosphate (58976-48-0) + (Rp)-adenosine 5'-O-(1-thiotriphosphate) (58976-49-1)

Guidance literature:

With ethylenediaminetetraacetic acid; potassium chloride; ATP; magnesium chloride; In water; water-d2; Product distribution; R 97M (Arg-97 to Met) mutant AK and other mutant enzyme of adenylate kinase;

DOI:10.1021/ja00024a065

upstream raw materials:

AMPS

adenosine

Downstream raw materials:

ATP

Refernces

• 1、 Moran, John R.,Whitesides, George M.. "A Practical Enzymatic Synthesis of (SP)-Adenosine 5'-O-(1-Thiotriphosphate) ((SP)-ATP-α-S)". . p. 704 - 706. Retrieved 2007/10/02.