Diphenylphosphinamide

Base Information

• Chemical Name: Diphenylphosphinamide
• CAS No.: 5994-87-6
• Molecular Formula: C12H12NOP
• Molecular Weight: 217.207
• Hs Code.: 2924299090
• European Community (EC) Number: 626-207-1
• DSSTox Substance ID: DTXSID40357449
• Nikkaji Number: J900.162J
• Mol file: 5994-87-6.mol

Synonyms:Diphenylphosphinamide;P,P-diphenylphosphinic amide;5994-87-6;[amino(phenyl)phosphoryl]benzene;[amino(phenyl)phosphoroso]benzene;MFCD00014766;Diphenyl phosphinic acid amide;Diphenylphosphinamide, 97%;C12H12NOP;DTXSID40357449;RIGIWEGXTTUCIQ-UHFFFAOYSA-N;AKOS004909980;AC-31067;SY109328;CS-0097857;FT-0635934;D70328;A832549

Chemical Property of Diphenylphosphinamide

Chemical Property:

• Vapor Pressure: 1.3E-05mmHg at 25°C
• Melting Point: 160-162°C
• Refractive Index: 1.602
• Boiling Point: 368.1°C at 760 mmHg
• PKA: 1.56±0.70(Predicted)
• Flash Point: 176.4°C
• PSA: 52.90000
• Density: 1.2g/cm³
• LogP: 2.57450
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Soluble in chloroform, nitromethane, nitrobenzene.
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 217.065651004
• Heavy Atom Count: 15
• Complexity: 220

Purity/Quality:

99% ^*data from raw suppliers

Diphenylphosphinamide 98% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)P(=O)(C2=CC=CC=C2)N
• Uses: Diphenylphosphinamide is used to furnish 5H-oxazol-4-ones with diastereoselectivity and enantioselectivity.

Technology Process of Diphenylphosphinamide

There total 64 articles about Diphenylphosphinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

chloro-diphenylphosphine (1079-66-9,74391-44-9) → diphenylphosphinamide (5994-87-6)

Guidance literature:

chloro-diphenylphosphine; With triethylamine; acetone oxime; In dichloromethane; at -70 - 20 ℃;

With ammonium hydroxide; for 0.75h;

DOI:10.1021/jo0516483

Reference yield: 96.0%

Diphenylphosphinic chloride (1499-21-4) → diphenylphosphinamide (5994-87-6)

Guidance literature:

With ammonia; In dichloromethane; at -78 - 20 ℃;

DOI:10.1016/j.tetlet.2014.08.122

Reference yield: 91.0%

N-(Diphenylphosphinothioyl)-O-benzoylhydroxylamine (153908-59-9) → benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) + diphenylphosphinamide (5994-87-6) + diphenylphosphinothioate (119862-26-9)

Guidance literature:

With sodium methylate; In methanol; for 0.25h;

DOI:10.1016/S0040-4039(00)61519-8

upstream raw materials:

Diphenylphosphinic chloride

diphenylphosphine oxide

thiophene-2-carbaldehyde

N-[(1E)-1-phenylethylidene]-P,P-diphenylphosphinic amide

Downstream raw materials:

3-nitrobenzamide

N-propyl-P,P-diphenylphosphinic amide

(E)-N-(4-chlorobenzylidene)-P,P-diphenylphosphinic amide

N-(4-chlorobenzylidene)-P,P-diphenylphosphinic amide

Refernces

• 1、 Kuroboshi, Manabu,Masumoto, Yasunari,Tanaka, Hideo. "Electrooxidation of chlorodiphenylphosphine under ammonia atmosphere. Synthesis of 2,2,4,4,6,6-hexaphenylcyclotriphosphazene and iminobis(Aminodiphenylphosphorus) chloride". . p. 1258 - 1264. Retrieved 2019/12/23.
• 2、 Wahl, Benoit,Cabré, Albert,Woodward, Simon,Lewis, William. "Nucleophilic addition of TMSCCl3 to N-phosphinoyl benzaldimines: A route to N-phosphinoyl-α-(trichloromethyl)benzylamines". supporting information. p. 5829 - 5831. Retrieved 2015/02/02.