1-Deoxy-1-(2-hydroxyethylamino)-D-glucitol

Base Information

• Chemical Name: 1-Deoxy-1-(2-hydroxyethylamino)-D-glucitol
• CAS No.: 54662-27-0
• Molecular Formula: C8H19NO6
• Molecular Weight: 225.242
• Hs Code.: 2922199090
• European Community (EC) Number: 691-404-1
• Nikkaji Number: J2.306.125B
• Mol file: 54662-27-0.mol

Synonyms:54662-27-0;1-DEOXY-1-(2-HYDROXYETHYLAMINO)-D-GLUCITOL;(2R,3R,4R,5S)-6-((2-Hydroxyethyl)amino)hexane-1,2,3,4,5-pentaol;n-(2-hydroxyethyl)glucamine;n-(2-hydroxyethyl)-d-glucamine;(2R,3R,4R,5S)-6-(2-hydroxyethylamino)hexane-1,2,3,4,5-pentol;1-Deoxy-1-(hydroxyethylamino)-D-glucitol;1-Deoxy-1-[(2-hydroxyethyl)amino]-D-glucitol;1-Deoxy-1-(2-hydroxyethylamino)-D-glucitol;N-(beta-Hydroxyethyl)glucamine;N-(2-hydroxyethyl) glucamine;SCHEMBL720003;N-(beta-hydroxyethyl)-glucamine;BS-28552;DB-216083;W-203062;(2R,3R,4R,5S)-6-[(2-HYDROXYETHYL)AMINO]HEXANE-1,2,3,4,5-PENTOL

Chemical Property of 1-Deoxy-1-(2-hydroxyethylamino)-D-glucitol

Chemical Property:

• Vapor Pressure: 3.97E-15mmHg at 25°C
• Refractive Index: 1.577
• Boiling Point: 565.2°C at 760 mmHg
• Flash Point: 277.2°C
• PSA: 133.41000
• Density: 1.444g/cm³
• LogP: -3.60490
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly), Water (Slightly)
• XLogP3: -4
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 8
• Exact Mass: 225.12123733
• Heavy Atom Count: 15
• Complexity: 158

Purity/Quality:

99%min ^*data from raw suppliers

N-(2-Hydroxyethyl)-D-glucamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CO)NCC(C(C(C(CO)O)O)O)O
• Isomeric SMILES: C(CO)NC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
• Uses: 1-Deoxy-1-(2-hydroxyethylamino)-d-glucitol, is a key intermediate for the synthesis of Miglitol (M344200), which is a potent α-glucosidase inhibitor, used as a new antidiabetic drug. N-(2-Hydroxyethyl)-D-glucamine, is a key intermediate for the synthesis of Miglitol (M344200), which is a potent α-glucosidase inhibitor, used as a new antidiabetic drug.

Technology Process of 1-Deoxy-1-(2-hydroxyethylamino)-D-glucitol

There total 3 articles about 1-Deoxy-1-(2-hydroxyethylamino)-D-glucitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.9%

D-Glucose (2280-44-6) + ethanolamine (141-43-5) → 1-deoxy-1-(2-hydroxyethylamino)-D-glucitol (54662-27-0)

Guidance literature:

With palladium 10% on activated carbon; In methanol; water; at 58 ℃; for 3.5h; under 15001.5 Torr; Autoclave;

Reference yield:

D-glucose (50-99-7) + ethanolamine (141-43-5) → 1-deoxy-1-(2-hydroxyethylamino)-D-glucitol (54662-27-0)

Guidance literature:

Reference yield:

glucose (50-99-7,59-23-4,921-60-8,1949-88-8,1990-29-0,2152-76-3,2595-97-3,2595-98-4,3458-28-4,4205-23-6,5934-56-5,5978-95-0,5987-68-8,6027-89-0,6038-51-3,7635-11-2,10030-80-5,15572-79-9,19163-87-2,23567-25-1,26566-61-0,30077-17-9,31103-86-3,39665-52-6,40866-07-7,58367-01-4,58407-05-9,58407-06-0,83198-69-0,83198-70-3,83198-71-4,93780-23-5,145920-48-5) + ethanolamine (141-43-5) → 1-deoxy-1-(2-hydroxyethylamino)-D-glucitol (54662-27-0)

Guidance literature:

With nickel kieselguhr; water; at 90 - 110 ℃; under 102971 Torr; Hydrogenation;

upstream raw materials:

glucose

ethanolamine

D-glucose

D-Glucose

Refernces

• 1、 -. "Preparation method of migltol intermediate 1-deoxy-1-(2-hydroxyethylamino)-D-glucitol". Paragraph 0020-0021; 0022-0023; 0024-0025. . Retrieved 2018/06/15.