4,7-Dichloro-2-phenyl-quinazoline

Base Information

• Chemical Name: 4,7-Dichloro-2-phenyl-quinazoline
• CAS No.: 54665-92-8
• Molecular Formula: C14H8Cl2N2
• Molecular Weight: 275.13
• Hs Code.: 2933990090
• Mol file: 54665-92-8.mol

Synonyms:4,7-Dichloro-2-phenylquinazoline;

Chemical Property of 4,7-Dichloro-2-phenyl-quinazoline

Chemical Property:

• Boiling Point: 332.6 °C at 760 mmHg
• Flash Point: 185.1 °C
• PSA: 25.78000
• Density: 1.381 g/cm³
• LogP: 4.60360
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4,7-Dichloro-2-phenyl-quinazoline 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,7-Dichloro-2-phenyl-quinazoline

There total 5 articles about 4,7-Dichloro-2-phenyl-quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.6%

7-chloro-5-methyl-2-phenylquinazolin-4(3H)-one (7012-94-4) → 4,7-dichloro-2-phenylquinazoline (54665-92-8)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; at 50 ℃; for 6h;

DOI:10.1021/acs.jmedchem.6b01787

Reference yield:

7-chloro-2-phenyl-4H-benzo[d][1,3]oxazin-4-one (7033-52-5) → 4,7-dichloro-2-phenylquinazoline (54665-92-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium hydroxide / ethanol / 12 h / 80 °C / Sealed tube

2: thionyl chloride; N,N-dimethyl-formamide / 6 h / 50 °C

With ammonium hydroxide; thionyl chloride; N,N-dimethyl-formamide; In ethanol;

DOI:10.1021/acs.jmedchem.6b01787

Reference yield:

benzoyl chloride (98-88-4) → 4,7-dichloro-2-phenylquinazoline (54665-92-8)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 12.5 h / 20 °C / Cooling with ice

2: ammonium hydroxide / ethanol / 12 h / 80 °C / Sealed tube

3: thionyl chloride; N,N-dimethyl-formamide / 6 h / 50 °C

With pyridine; ammonium hydroxide; thionyl chloride; N,N-dimethyl-formamide; In ethanol;

DOI:10.1021/acs.jmedchem.6b01787

upstream raw materials:

7-chloro-5-methyl-2-phenylquinazolin-4(3H)-one

7-chloro-2-phenyl-4H-benzo[d][1,3]oxazin-4-one

benzoyl chloride

2-Amino-4-chlorobenzoic acid

Refernces

• 1、 -. "6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS". Page/Page column 419-420. . Retrieved 2008/06/13.