Indoline-2-carboxylic Acid Ethyl Ester

Base Information

• Chemical Name: Indoline-2-carboxylic Acid Ethyl Ester
• CAS No.: 50501-07-0
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Hs Code.: 2933990090
• Mol file: 50501-07-0.mol

Synonyms:INDOLINE-2-CARBOXYLIC ACID ETHYL ESTER

Chemical Property of Indoline-2-carboxylic Acid Ethyl Ester

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 53.0 to 57.0 °C
• Refractive Index: 1.538
• Boiling Point: 307.151ºC at 760 mmHg
• PKA: 3.24±0.40(Predicted)
• Flash Point: 139.56ºC
• PSA: 38.33000
• Density: 1.134g/cm3
• LogP: 1.72430
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

Ethyl Indoline-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Indoline-2-carboxylic Acid Ethyl Ester

There total 4 articles about Indoline-2-carboxylic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + indolin-2-yl carboxylic acid (16851-56-2,78348-24-0) → (S)-2,3-dihydro-1H-indole-2-carboxylic acid,ethyl ester (50501-07-0)

Guidance literature:

With sulfuric acid; for 24h; Reflux;

DOI:10.1002/chem.201703642

Reference yield:

indolin-2-yl carboxylic acid (16851-56-2,78348-24-0) → (S)-2,3-dihydro-1H-indole-2-carboxylic acid,ethyl ester (50501-07-0)

Guidance literature:

With hydrogenchloride; sodium chloride; potassium carbonate; In 1,4-dioxane; ethanol;

Reference yield:

2-carbethoxyindole (3770-50-1,117770-52-2) → (S)-2,3-dihydro-1H-indole-2-carboxylic acid,ethyl ester (50501-07-0)

Guidance literature:

With triethylsilane; In trifluoroacetic acid; for 2h; Heating;

DOI:10.1021/jm00392a005

upstream raw materials:

2-carbethoxyindole

ethanol

indolin-2-yl carboxylic acid

Downstream raw materials:

ethyl 1-<3-(benzoylthio)-2-methylpropionyl>indoline-2-carboxylate

2,3-Dihydro-1H-indol-2-ylmethanol

(S)-indoline-2-carboxylic acid

ethyl (R)-indoline-2-carboxylate

Refernces

• 1、 Lee, Sunkyung,Yi, Kyu Yang,Kim, Soo-Kyung,Suh, Jeehee,Kim, Nak Jeong,Yoo, Sung-Eun,Lee, Byung Ho,Seo, Ho Won,Kim, Sun-Ok,Lim, Hong. "Cardioselective anti-ischemic ATP-sensitive potassium channel (KATP) openers: Benzopyranyl indoline and indole analogues". . p. 459 - 471. Retrieved 2007/10/03.
• 2、 Collot, Valerie,Schmitt, Martine,Marwah, Ashok K.,Norberg, Bernadette,Bourguignon, Jean-Jacques. "Synthesis of 3-phenylindoline-2-carboxamides as semi-rigid phenylalanine mimetics". . p. 8033 - 8036. Retrieved 2007/10/03.