Pyrazinecarbonitrile, 6-amino- (9CI)

Base Information

• Chemical Name: Pyrazinecarbonitrile, 6-amino- (9CI)
• CAS No.: 59489-39-3
• Molecular Formula: C5H4N4
• Molecular Weight: 120.114
• Hs Code.: 2933990090
• Mol file: 59489-39-3.mol

Synonyms:2-Amino-6-cyanopyrazine;6-Amino-2-pyrazinecarbonitrile,;2-Pyrazinecarbonitrile, 6-amino-;6-aminopyrazine-2-carbonitrile;

Chemical Property of Pyrazinecarbonitrile, 6-amino- (9CI)

Chemical Property:

• Boiling Point: 367.8ºC at 760 mmHg
• Flash Point: 176.3 ºC
• PSA: 75.59000
• Density: 1.34 g/cm³
• LogP: 0.51168
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%Min ^*data from raw suppliers

2-Amino-6-cyanopyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazinecarbonitrile, 6-amino- (9CI)

There total 2 articles about Pyrazinecarbonitrile, 6-amino- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Pyrazin-N-Oxid(PyzNO) (2423-65-6) + pyrazinamide (98-96-4) → 6-aminopyrazine-2-carbonitrile (59489-39-3) + 2-chloro-3-cyanopyrazine (55557-52-3)

Guidance literature:

With dihydrogen peroxide; trichlorophosphate; In N-methyl-acetamide; water; acetic acid; butan-1-ol;

Reference yield:

trimethylsilyl cyanide (7677-24-9) + 3-aminopyrazine 1-oxide (6863-77-0) → 2-amino-3-pyrazinonitrile (25911-65-3) + 6-aminopyrazine-2-carbonitrile (59489-39-3)

Guidance literature:

With triethylamine; In acetonitrile; for 6h; Heating;

Reference yield:

5-chloro-7-methoxy-6-(4-methoxyphenyl)-2,3-diphenylpyrazolo[1,5-a]pyrimidine + 6-aminopyrazine-2-carbonitrile (59489-39-3) → 6-(7-methoxy-6-(4-methoxyphenyl)-2,3-diphenylpyrazolo[1,5-a]pyrimidin-5-ylamino)pyrazine-2-carbonitrile

Guidance literature:

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 110 ℃; for 1h; Inert atmosphere; Microwave irradiation;

upstream raw materials:

trimethylsilyl cyanide

3-aminopyrazine 1-oxide

Pyrazin-N-Oxid(PyzNO)

pyrazinamide

Refernces

• 1、 -. "Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas". . . Retrieved 2008/06/13.