2-(2-P-TOLYL)-4-THIAZOLIDINECARBOXYLIC ACID

Base Information

• Chemical Name: 2-(2-P-TOLYL)-4-THIAZOLIDINECARBOXYLIC ACID
• CAS No.: 59668-69-8
• Molecular Formula: C11H13NO2S
• Molecular Weight: 223.296
• Hs Code.: 2934999090
• Mol file: 59668-69-8.mol

Synonyms:2-(2-P-TOLYL)-4-THIAZOLIDINECARBOXYLIC ACID;2-(4-METHYLPHENYL)-1,3-THIAZOLANE-4-CARBOXYLIC ACID;2-P-TOLYL-THIAZOLIDINE-4-CARBOXYLIC ACID

Chemical Property of 2-(2-P-TOLYL)-4-THIAZOLIDINECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 1.13E-08mmHg at 25°C
• Refractive Index: 1.602
• Boiling Point: 444.2°C at 760 mmHg
• Flash Point: 222.5°C
• PSA: 74.63000
• Density: 1.261g/cm³
• LogP: 2.11200

Purity/Quality:

98%Min ^*data from raw suppliers

2-p-Tolyl-thiazolidine-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-p-Tolyl-thiazolidine-4-carboxylic Acid is used as a phosphatase inhibitors as leads for osteoporosis chemotherapeutics

Technology Process of 2-(2-P-TOLYL)-4-THIAZOLIDINECARBOXYLIC ACID

There total 2 articles about 2-(2-P-TOLYL)-4-THIAZOLIDINECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

l-cysteine hydrochloride (52-89-1) + 4-methyl-benzaldehyde (104-87-0) → (2R,4R)-2-(4-methylphenyl)-1,3-thiazolidine-4-carboxylic acid (59668-69-8) + (2S,4R)-2-(4-methylphenyl)-1,3-thiazolidine-4-carboxylic acid (82597-71-5)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; water; optical yield given as %de; Heating;

DOI:10.1134/S107036321010021X

Reference yield:

l-cysteine hydrochloride (52-89-1) + 4-methyl-benzaldehyde (104-87-0) → (2R,4R)-2-(4-methylphenyl)-1,3-thiazolidine-4-carboxylic acid (59668-69-8)

Guidance literature:

With potassium acetate; In ethanol;

DOI:10.1021/jm00230a004

Reference yield:

(2R,4R)-2-(4-methylphenyl)-1,3-thiazolidine-4-carboxylic acid (59668-69-8) → ((4R)-3-acetyl-2c-p-tolyl-thiazolidin-4r-yl)-acetic acid methyl ester (59668-78-9)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂O

2: (i) DCC, THF, (ii) /BRN= 102415/, Et₂O

3: Irradiation

In water;

DOI:10.1021/jm00230a004

upstream raw materials:

l-cysteine hydrochloride

4-methyl-benzaldehyde

Downstream raw materials:

(4R)-cis-2-p-tolyl-thiazolidine-4-carboxylic acid methyl ester

(4R)-2c-p-tolyl-thiazolidine-3,4r-dicarboxylic acid 3-ethyl ester 4-methyl ester

3c,8t-di-p-tolyl-(5ar,10at)-tetrahydro-bisthiazolo[3,4-a;3',4'-d]pyrazine-5,10-dione

(4R)-2c-p-tolyl-thiazolidine-3,4r-dicarboxylic acid 3-ethyl ester

Refernces

• 1、 Skvortsov,Uvarov,De Vekki,Studentsov,Skvortsov. "Conformational analysis, spectral and catalytic properties of 1,3-thiazolidines, ligands for acetophenone hydrosilylation with diphenylsilane". scheme or table. p. 2007 - 2021. Retrieved 2011/02/18.