2-Pyridinecarbonitrile,5-amino-3-fluoro-(9CI)

Base Information

• Chemical Name: 2-Pyridinecarbonitrile,5-amino-3-fluoro-(9CI)
• CAS No.: 573763-07-2
• Molecular Formula: C6H4FN3
• Molecular Weight: 137.117
• Hs Code.: 2933399990
• Mol file: 573763-07-2.mol

Synonyms:5-Amino-3-fluoro-pyridine-2-carbonitrile;

Chemical Property of 2-Pyridinecarbonitrile,5-amino-3-fluoro-(9CI)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.562
• Boiling Point: 349.915 °C at 760 mmHg
• PKA: -1.32±0.10(Predicted)
• Flash Point: 165.423 °C
• PSA: 62.70000
• Density: 1.354 g/cm³
• LogP: 1.25578

Purity/Quality:

98%min ^*data from raw suppliers

5-Amino-3-fluoropyridine-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridinecarbonitrile,5-amino-3-fluoro-(9CI)

There total 5 articles about 2-Pyridinecarbonitrile,5-amino-3-fluoro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

C6H2FN3O3 (1344734-70-8) → 5-amino-3-fluoro-2-pyridinecarbonitrile (573763-07-2)

Guidance literature:

With iron; acetic acid; at 40 ℃;

DOI:10.1016/j.bmcl.2011.08.080

Reference yield:

3-fluoro-5-nitropicolinonitrile (573763-02-7) → 5-amino-3-fluoro-2-pyridinecarbonitrile (573763-07-2)

Guidance literature:

With iron; acetic acid; at 65 ℃;

Reference yield:

3-fluoro-5-nitropicolinonitrile (573763-02-7) + iron (7439-89-6) → 5-amino-3-fluoro-2-pyridinecarbonitrile (573763-07-2)

Guidance literature:

In acetic acid; ethyl acetate;

upstream raw materials:

3-fluoro-5-nitropicolinonitrile

iron

C₆H₃FN₂O

C₆H₂FN₃O₃

Downstream raw materials:

C₂₃H₂₅F₂N₅O₃

C₃₂H₃₃F₂N₇O₅S

1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(5-fluoro-6-(hydroxymethyl)pyridin-3-yl)urea

Refernces

• 1、 -. "SUBSTITUTED HETEROAROMATIC PYRAZOLE-CONTAINING CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS". . . Retrieved 2013/03/26.
• 2、 Duan, Maosheng,Kazmierski, Wieslaw M.,Chong, Pek Y.,DeAnda, Felix,Edelstein, Mark,Ferris, Rob,Peckham, Jennifer,Wheelan, Pat,Xiong, Zhiping,Zhang, Huichang,Nishizawa, Rena,Takaoka, Yoshikazu. "Discovery of novel pyridyl carboxamides as potent CCR5 antagonists and optimization of their pharmacokinetic profile in rats". . p. 6470 - 6475. Retrieved 2011/11/29.