Pyrimidine, 4,5-dimethyl- (6CI,7CI,8CI,9CI)

Base Information

• Chemical Name: Pyrimidine, 4,5-dimethyl- (6CI,7CI,8CI,9CI)
• CAS No.: 694-81-5
• Molecular Formula: C6H8 N2
• Molecular Weight: 108.143
• Hs Code.: 2933599090
• Mol file: 694-81-5.mol

Synonyms:4,5-Dimethylpyrimidine

Chemical Property of Pyrimidine, 4,5-dimethyl- (6CI,7CI,8CI,9CI)

Chemical Property:

• Melting Point: 3°C
• Refractive Index: 1.4880 (estimate)
• Boiling Point: 192.78°C (rough estimate)
• PSA: 25.78000
• Density: 1.0265 (rough estimate)
• LogP: 1.09340

Purity/Quality:

98% ^*data from raw suppliers

4,5-Dimethylpyrimidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrimidine, 4,5-dimethyl- (6CI,7CI,8CI,9CI)

There total 9 articles about Pyrimidine, 4,5-dimethyl- (6CI,7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

1,3,5-Triazine (290-87-9) + butanone (78-93-3) → 4,5-dimethylpyrimidine (694-81-5)

Guidance literature:

With morpholine; triethylamine; In methanol; at 90 ℃; for 72h; regioselective reaction;

DOI:10.1039/c5ra16995j

Reference yield: 17.0%

2,6-dimethylpyrazine (108-50-9) → 2,4-dimethylpyrimidine (14331-54-5) + 4,5-dimethylpyrimidine (694-81-5)

Guidance literature:

for 0.0833333h; under 1 - 1.5 Torr; Irradiation;

DOI:10.24820/ark.5550190.p010.267

Reference yield: 5.7%

2,4-dimethylpyrimidine (14331-54-5) → 3,6-dimethylpyridazine (1632-74-2) + 4,5-dimethylpyrimidine (694-81-5) + 2,6-dimethylpyrazine (108-50-9)

Guidance literature:

for 0.0833333h; under 1 - 1.5 Torr; Irradiation;

DOI:10.24820/ark.5550190.p010.267

upstream raw materials:

2,4-dichloro-5,6-dimethylpyrimidine

formamide

dimethyl sulfate

butanone

Downstream raw materials:

4,5-Dimethyl-pyrimidine-2-carbonitrile

5,6-Dimethyl-pyrimidine-4-carbonitrile

(5-methylpyrimidin-4-yl)methanamine

4,5-Dimethyl-pyrimidine 1-oxide

Refernces

• 1、 -. "AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES". Paragraph 0253. . Retrieved 2016/06/21.
• 2、 Strekowski, Lucjan,Wydra, Roman L.,Janda, Lubomir,Harden, Donald B.. "Highly Regioselective Bromination Reactions of Polymethylpyrimidines". . p. 5610 - 5614. Retrieved 2007/10/02.